Sphingomyelinase C from Streptomyces sp A9107: Unusual primary structure for bacterial sphingomyelinase C

Sogabe T; Ota H; Iwasaki M; Sakasegawa S; Tamura T

Journal of Bioscience and Bioengineering, Vol.114, No.4, 398-401, 2012

DOI10.1016/j.jbiosc.2012.05.005 Export Citation

Sphingomyelinase C from Streptomyces sp A9107: Unusual primary structure for bacterial sphingomyelinase C

Sogabe T, Ota H, Iwasaki M, Sakasegawa S, Tamura T

A sphingomyelinase C (SMase) was identified in the culture supernatant of Streptomyces sp. A9107 (S-SMase). Although S-SMase seems to be a typical bacterial SMase, the primary structure of S-SMase was unusual for known bacterial SMase. The gene was functionally overexpressed in the culture medium of recombinant Rhodococcus erythropolis. (c) 2012, The Society for Biotechnology, Japan. All rights reserved.

Keywords:Sphingomyelin;Sphingomyelinase C;Streptomyces sp.;Heterologous extracellular overexpression;Rhodococcus erythropolis