Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues

Dong SW; Shang SY; Li JF; Tan ZP; Dean T; Maeda A; Gardella TJ; Danishefsky SJ

Journal of the American Chemical Society, Vol.134, No.36, 15122-15129, 2012

Dong SW, Shang SY, Li JF, Tan ZP, Dean T, Maeda A, Gardella TJ, Danishefsky SJ

Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation.