The air-side heat transfer and flow characteristics of cross-flow multiport slab mesochannel heat exchanger are investigated experimentally in this article. The multiport slab mesochannel heat exchanger consists of 15 finned aluminum slabs; each slab contains 68 flow channels of 1 mm circular diameter. The cold deionized water at a constant mass flow rate was forced to flow through the mesochannels, whereas the hot air at different velocities was allowed to pass through the finned passages of the heat exchanger core in cross-flow orientation. The heat transfer and fluid flow key parameters were examined in the region of the air-side Reynolds number in the range of 972-2758, with a constant water-side Reynolds number of 135. The effect of air-side Reynolds number on air-side Nusselt number was examined and a general correlation of Nusselt number with Reynolds number was obtained. The Nusselt number value was found to be higher in comparison with other research works for the corresponding Reynolds number range. The multiport mesochannel flat slab geometry has offered uniform temperature distribution into the core. This uniform temperature distribution leads to higher heat transfer over stand-alone inline flow tube bank.