The intrinsic kinetics of the catalytic combustion of a trace amount of ethylene in a CO2 stream over a Cu-Mn-O catalyst prepared with a coprecipitation method is investigated. The experiments are carried out in a fixed-bed reactor with 0.3 g of catalyst in a low temperature range (470 to 620 K) and varying the concentration of C2H4 and O-2 in the feed stream. The power rate law, Langmuir-Hinshelwood (LH), Eley-Rideal (ER), and Mars-van Krevelen (MVK) models are compared. The residual error distribution of the ethylene conversion is employed to optimize the model equations. The extended MVK model containing desorption terms of the combustion products fit the data well. The pilot test with a fixed-bed reactor and a commercial feed stream is carried out, and the macro kinetic equations are obtained. Combined with the extended MVK model equations of the intrinsic kinetics, the effectiveness factor is calculated, which gives further prediction of the performance of the extruded catalyst under commercial conditions.