Mesoporous TS-1 (M-TS-1) was synthesized using a hybrid SiO2-TiO2 xerogel combined with an organosilane precursor. Prepared samples were characterized by XRD, UV-vis spectroscopy, SEM, and N-2 adsorption-desorption measurement. M-TS-1, prepared in 2 days, showed high crystallinity and the best textural properties among the samples. The N2 adsorption-desorption isotherms of M-TS-1 exhibited a hysteresis loop at pressure higher than P/P-0 = 0.4, clearly indicating the existence of mesopores. M-TS-1 has significantly larger mesopore volume (0.48 cm(3)/g) than that of conventional TS-1 (0.07 cm(3)/g), and showed a narrow peak centered at ca. 6.3 nm. In the oxidative desulfurization reaction, M-TS-1 was more active than conventional TS-1 at the same Ti-loading; M-TS-1 produced a dibenzothiophene (DBT) conversion of 96%, whereas conventional TS-1 produced a final DBT conversion of 5.6% after a reaction time of 180 min. Oxidative desulfurization over TS-1 was influenced both by electron density and steric hindrance in the sulfur compounds tested. (C) 2012 Elsevier Ltd. All rights reserved.