In this work, the regeneration of a polymeric resin column saturated with ethanol with air purge and external heating has been studied. A theoretical model is proposed for describing the mass and heat transfers in the system, and it has been validated with experimental data. This model can be used for simulating the regeneration step in a concentration-thermal swing adsorption process for fuel-grade ethanol production. The model has been used to analyze the process dynamic behavior, and to compare the performance of the regeneration step using external heating and hot air purge.