Synthesis of pH-responsive and adhesive super-absorbent hydrogel through bulk polymerization

Bo Mi Shin; Ji-Heung Kim; Dong June Chung

Macromolecular Research, Vol.21, No.5, 582-587, May, 2013

DOI10.1007/s13233-013-1051-4 Export Citation

Synthesis of pH-responsive and adhesive super-absorbent hydrogel through bulk polymerization

Bo Mi Shin, Ji-Heung Kim¹, and Dong June Chung^†

Department of Polymer Science and Engineering, Sungkyunkwan University, Gyeonggi, 440-746, Korea
¹Department of Chemical Engineering, Sungkyunkwan University, Gyeonggi, 440-746, Korea

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Sodium acrylate (AANa) and hydroxyethyl methacrylate (HEMA) were synthesized by bulk polymerization technique to achieve a pH-responsive, super-absorbent hydrogel (SHG) copolymer. The synthesized copolymer was confirmed by FTIR spectroscopy. The pH responsive behavior of the SHG with different monomer ratios of HEMA and AA was investigated, and the SHG showed significant swelling properties at pH 7. The hydrogels were evaluated for the influences of crosslinking agent content, changes in the surface/cross-sectional morphology according to the degree of crosslinking, the water-absorbing properties of swellable SHG, and the adhesion properties to other polymer surfaces. The SHG hydrogel also exhibited good biocompatibility, low cytotoxicity, and high cell viability. The synthesized SHG hydrogel could be used for wound dressing materials in clinical applications requiring high absorption capacity when body fluids are heavily secreted from a wound site. Poly(AA-co-HEMA) hydrogels (SHG) may also have potential uses in biomedical applications such as wound healing and tissue engineering.

Keywords:hydroxyethyl methacrylate (HEMA);super-absorbent hydrogel;pH-responsive;wound dressing;bulk polymerization

[References]

Buchhlz FL, Graham T, Modern Superabsorbent Polymer Technology, Wiley-VCH, New York, 1998.
Sawai T, Yamazaki S, Ishigami Y, Ikariyama Y, Aizawa M, Macromolecules, 24, 5801 (1991)
Pourjavadi A, Amini-Fazl MS, Hosseinzadeh H, Macromol. Res., 13(1), 45 (2005)
Gao T, Wang W, Wang A, Macromol. Res., 19(7), 739 (2011)
Fanta GF, Burr RC, Rist CE, J. Appl. Polym. Sci., 10, 929 (1966)
Fanta GF, Burr RC, Russell CR, Rist CE, J. Appl. Polym. Sci., 11, 457 (1967)
Fanta GF, Burr RC, Rist CE, J. Polym. Sci. B: Polym. Phys., 4, 765 (1966)
Athawale VD, Vidyagauri L, Carbohydr. Polym., 35, 21 (1998)
Lin RX, Huang YL, Niu A, J. Polym. Mater. Sci. Eng., 15, 118 (1999)
Tian DT, Guo JS, Xie LQ, J. Appl. Chem., 14, 18 (1997)
Umbreit GR, Houtman RL, J. Pharm. Sci., 56, 349 (1967)
Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR, J. Natl. Cancer. Inst., 82, 1107 (1990)
Wen S, Yin X, Stevenson WTK, J. Appl. Polym. Sci., 42, 1399 (1991)
Son YK, Jung YP, Kim JH, Chung DJ, Macromol. Res., 14(3), 394 (2006)

[Referenced By]

[Related Articles]

[1] Buchhlz FL, Graham T, Modern Superabsorbent Polymer Technology, Wiley-VCH, New York, 1998.

[2] Sawai T, Yamazaki S, Ishigami Y, Ikariyama Y, Aizawa M, Macromolecules, 24, 5801 (1991)

[3] Pourjavadi A, Amini-Fazl MS, Hosseinzadeh H, Macromol. Res., 13(1), 45 (2005)

[4] Gao T, Wang W, Wang A, Macromol. Res., 19(7), 739 (2011)

[5] Fanta GF, Burr RC, Rist CE, J. Appl. Polym. Sci., 10, 929 (1966)

[6] Fanta GF, Burr RC, Russell CR, Rist CE, J. Appl. Polym. Sci., 11, 457 (1967)

[7] Fanta GF, Burr RC, Rist CE, J. Polym. Sci. B: Polym. Phys., 4, 765 (1966)

[8] Athawale VD, Vidyagauri L, Carbohydr. Polym., 35, 21 (1998)

[9] Lin RX, Huang YL, Niu A, J. Polym. Mater. Sci. Eng., 15, 118 (1999)

[10] Tian DT, Guo JS, Xie LQ, J. Appl. Chem., 14, 18 (1997)

[11] Umbreit GR, Houtman RL, J. Pharm. Sci., 56, 349 (1967)

[12] Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR, J. Natl. Cancer. Inst., 82, 1107 (1990)

[13] Wen S, Yin X, Stevenson WTK, J. Appl. Polym. Sci., 42, 1399 (1991)

[14] Son YK, Jung YP, Kim JH, Chung DJ, Macromol. Res., 14(3), 394 (2006)