In the present study, we investigated the adhesive performances of polyacrylamide-based hydrogels intended to be used as dermatological patches. Accordingly, we have prepared conventional copolymer poly(acrylamide-co-hydroxyethyl methacrylate) hydrogels and nanocomposite copolymer poly(acrylamide-co-hydroxyethyl methacrylate) hydrogels filled with poly(butyl acrylate) nanoparticles. We evaluated their adhesive properties when they were applied to different substrates (equivalent human skin, stainless steel) using a probe tack test. The adhesion energy was found to be related to the chemical composition and the rheological properties of the hydrogels which were also measured.