One of the challenges in the application of structural adhesive joints is the prediction of their long-term durability. During the service life, moisture diffuses into the adhesive layer and eventually degrades its fracture properties. Environmental degradation should thus be taken into consideration in the design and analysis of adhesive joints. This work first provides an overview, summarizing the recent efforts regarding the hygrothermal exposure of adhesive joints, accelerated aging methods, water diffusion modeling, and characterization of fracture properties in adhesively bonded joints. The second part presents a recent degradation methodology by which the fracture toughness evolution of adhesive joints can be predicted using fracture test data obtained using the accelerated open-faced degradation method.