Nanocomposite technology has been utilized to improve biocompatibility and mechanical property of biomedical catheter materials. In this study, graphene oxide (GeneO), graphene oxide complexes with 2-(methacryloyloxy)ethyl phosphorylcholine (GeneO-MPC), and modified polyethylene (PE/GeneO-MPC) nanocomposites applied in biomedical catheter materials field were synthesized and their bacteriostasis to E. coli and S. aureus was studied. According to the results of bacterial adhesion, PE/GeneO-MPC nanocomposites inhibited the growth of the mass of predominant bacteria. PE/GeneO-MPC could reduce platelet adhesion greatly as compared to PE, which displayed the improved anticoagulant property. The tensile strength and elongation of PE/GeneO-MPC nanocomposites were enhanced by 15.5 and 97.3%, respectively. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 129: 884-891, 2013