Journal of the American Chemical Society, Vol.135, No.9, 3387-3390, 2013
Palladium(0)-Catalyzed Alkynylation of C(sp(3))-H Bonds
The alkynylation of beta-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L-n] complexes to activate C(sp(3))-H bonds.