Mechanical properties of compliant double layered poly(L-lactide-co-ε-caprolactone) vascular graft

Sang-Hoon Kim; Cho Hay Mun; Youngmee Jung; Sang-Heon Kim; Dong-Ik Kim; Soo Hyun Kim

Macromolecular Research, Vol.21, No.8, 886-891, August, 2013

DOI10.1007/s13233-013-1095-5 Export Citation

Mechanical properties of compliant double layered poly(L-lactide-co-ε-caprolactone) vascular graft

Sang-Hoon Kim¹, Cho Hay Mun¹, Youngmee Jung¹, Sang-Heon Kim¹, Dong-Ik Kim², and Soo Hyun Kim^{1, 3, †}

¹Biomaterials Research Center, Division of Life & Health Sciences, Korea Institute of Science and Technology, Seoul, 136-791, Korea
²Division of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-230, Korea
³Graduate School, Korea University, Seoul, Korea

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We fabricated a tubular double-layered scaffold using two steps; poly(L-lactide-co-ε-caprolactone) (PLCL) gel spinning method and salt leaching. The objective of the present study was to characterize the mechanical properties of tubular double-layered PLCL scaffolds that had different wall thickness values. We evaluated the bio-vascular scaffold in terms of cardiovascular implants-tubular vascular prostheses in international standard; ANSI/AAMI/ISO 7198:1998/2001. According to the ISP 7198, PLCL had sufficient mechanical strength, burst strength, tensile strength to withstand blood pressure and had similar compliance to native vessels due to its elasticity. We applied the tubular vascular prostheses’ evaluation method using an existing surgical operation. The vascular scaffold, which had a similar compliance to native vessels, did not result in severe thrombosis in vivo for 4 weeks. Thus, this novel material holds great promise for use as a blood vessel substitute.

Keywords:poly(L-lactide-co-ε-caprolactone);gel-spinning molding technique;double-layered scaffold;dynamic compliance;vascular tissue engineering

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[Related Articles]

[1] Thomas AC, Campbell GR, Campbell JH, Cardiovasc. Pathol., 12, 271 (2003)

[2] Seifalian AM, Tiwari A, Hamilton G, Salacinski HJ, Artif. Organs, 26, 307 (2002)

[3] Isomatsu Y, Shin’oka T, Aoki M, Terada M, Takeuchi T, Hoshino S, Takanashi Y, Imai Y, Kurosawa H, Ann. Thorac. Surg., 78, 173 (2004)

[4] Boland ED, Matthews JA, Pawlowski KJ, Simpson DG, Wnek GE, Bowlin GL, Front. Biosci., 9, C1432 (2004)

[5] Greenwald S, Berry C, J. Pathol., 190, 292 (2000)

[6] Conte MS, Faseb J., 12, 43 (1998)

[7] Shum-Tim D, Stock U, Hrkach J, Shinoka T, Lien J, Moses MA, Stamp A, Taylor G, Moran AM, Landis W, Ann. Thorac. Surg., 68, 2298 (1999)

[8] Ratcliffe A, Matrix Biol., 19, 353 (2000)

[9] L’heureux N, Paquet S, Labbe R, Germain L, Auger FA, Faseb J., 12, 47 (1998)

[10] Freed L, Marquis J, Nohria A, Emmanual J, Mikos A, Langer R, J. Biomed. Mater. Res., 27, 11 (1993)

[11] Dame MK, Yu X, Garrido R, Bobrowski W, McDuffie JE, Murphy HS, Albassam M, Varani J, In Vitro Cell. Dev. Biol. Anim., 39, 402 (2003)

[12] Williamson MR, Coombes AGA, Biomaterials, 25, 459 (2004)

[13] Gogolewski S, Pennings A, J. Appl. Polym. Sci., 28, 1045 (1983)

[14] Inoguchi H, Kwon IK, Inoue E, Takamizawa K, Maehara Y, Matsuda T, Biomaterials, 27, 1470 (2006)

[15] Jeong SI, Kim BS, Lee YM, Ihn KJ, Kim SH, Kim YH, Biomacromolecules, 5(4), 1303 (2004)

[16] Jeong SI, Kim SH, Kim YH, Jung Y, Kwon JH, Kim BS, Lee YM, J. Biomater. Sci.-Polym. Ed., 15, 645 (2004)

[17] Jeong SI, Kwon JH, Lim JI, Cho SW, Jung Y, Sung WJ, Kim SH, Kim YH, Lee YM, Kim BS, Biomaterials, 26, 1405 (2005)

[18] Wise SG, Byrom MJ, Waterhouse A, Bannon PG, Ng MKC, Weiss AS, Acta Biomater., 7, 295 (2011)

[19] Lee SJ, Liu J, Oh SH, Soker S, Atala A, Yoo JJ, Biomaterials, 29, 2891 (2008)

[20] Marelli B, Alessandrino A, Fare S, Freddi G, Mantovani D, Tanzi MC, Acta Biomater., 6, 4019 (2010)

[21] Abbott WM, Megerman J, Hasson JE, L’Italien G, Warnock DF, J. Vasc. Surg., 5, 376 (1987)

[22] Kim SH, Chung E, Jung Y, Kim YH, J. Biomater. S, 21, 289 (2010)

[23] Sell S, McClure MJ, Barnes CP, Knapp DC, Walpoth BH, Simpson DG, Bowlin GL, Biomed. Mater., 1, 72 (2006)

[24] McClure MJ, Sell SA, Simpson DG, Walpoth BH, Bowlin GL, Acta Biomater., 6, 2422 (2010)

[25] Kim SH, Kwon JH, Chung MS, Chung E, Jung Y, Kim YH, J. Biomater. Sci.-Polym. Ed., 17, 1359 (2006)

[26] Hassan K , Kim SH, Park I, Lee SH, Kim SH, Jung Y, Kim SH, Kim SH, Macromol. Res., 19(2), 122 (2011)

[27] Kong X, Han B, Wang H, Li H, Xu W, Liu W, J. Biomed. Mater. Res., 100A, 1938 (2012)

[28] Hsu S, Karnbic H, Artificial organs, 21, 1247 (1997)

[29] Zhang L, Zhou JY, Lu QP, Wei YJ, Hu SS, Biotechnol. Bioeng., 99(4), 1007 (2008)

[30] McKenna KA, Hinds MT, Sarao RC, Wu PC, Maslen CL, Glanville RW, Babcock D, Gregory KW, Acta Biomater., 8, 225 (2012)

[31] Okuhn SP, Connelly DP, Calakos N, Ferrell L, Man- Xiang P, Goldstone J, J. Vasc. Surg., 9, 35 (1989)

[32] Wu MHD, Shi Q, Sauvage LR, Kaplan S, Hayashida N, Patel MD, Wechezak AR, Walker MW, Ann. Vasc. Surg., 7, 156 (1993)

[33] Sonoda H, Takamizawa K, Nakayama Y, Yasui H, Matsuda T, J. Biomed. Mater. Res. A, 65, 170 (2003)