Preparation and characterization of calcium phosphate cement of α-tricalcium phosphate-tetracalcium phosphate-dicalcium phosphate system incorporated with poly(γ-glutamic acid)

Young Baek Kim; Byung Min Lee; Myung Chul Lee; Insup Noh; Sung-Jae Lee; Sung Soo Kim

Macromolecular Research, Vol.21, No.8, 892-898, August, 2013

DOI10.1007/s13233-013-1109-3 Export Citation

Preparation and characterization of calcium phosphate cement of α-tricalcium phosphate-tetracalcium phosphate-dicalcium phosphate system incorporated with poly(γ-glutamic acid)

Young Baek Kim, Byung Min Lee, Myung Chul Lee¹, Insup Noh², Sung-Jae Lee³, and Sung Soo Kim^†

Department of Nanotechnology, PaiChai University, Daejeon, 302-735, Korea
¹Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, 110-744, Korea
²Department of Chemical and Biomacromolecular Engineering, Seoul National University of Science and Technology, Seoul, 139-743, Korea
³Department of Biomedical Engineering, Inje University, Gyeongnam, 621-749, Korea

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Polymeric calcium phosphate cements (PCPCs) were prepared from cement powders consisting of alphatricalcium phosphate (α-TCP), tetracalcium phosphate (TTCP) and dicalcium phosphate (DCP), and cement liquid with poly(γ-glutamic acid) (γ-PGA). The characteristics of calcium phosphate cements (CPCs), such as paste injectability, initial setting time, and compressive strength, were assessed. The injectability of PCPCs with a 0?30 wt% TTCP/DCP mixture was above 90%. The initial setting time decreased in concert with the amount of incorporated TTCP/DCP mixture and reached approximately 10-13 min when the amount of TTCP/DCP mixture was 10-30 wt%. The compressive strength of PCPC with the 30% equimolar TTCP/DCP mixture was approximately 18.4±3.5 MPa, whereas that of the CPC without the TTCP/DCP mixture was approximately 4.8±0.1 MPa.

Keywords:calcium phosphate cement;poly(γ-glutamic acid);tricalcium phosphate;tetracalcium phosphate

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Chow LC, Markovic M, Frukhtbeyn SA, Takagi S, Biomaterials, 26, 393 (2005)
Fernandez E, Ginebra MP, Boltong MG, Driessens FCM, Ginebra J, De Mayer EAP, Verbeeck RMH, Planell JA, J. Biomed. Mater. Res., 32, 367 (1996)
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[2] Kurashina K, Kurita H, Hirano M, de Blieck JMA, Klein CPAT, de Groot K, J. Mater. Sci. -Mater. Med., 6, 340 (1995)

[3] Yang DH, Park HN, Bae MS, Lee JB, Heo DN, Lee WJ, Park YM, Cho YH, Kim DS, Kwon IK, Macromol. Res., 20(6), 627 (2012)

[4] Brown WE, Chow IC, J. Dent. Res., 62, 672 (1983)

[5] Chohayeb AA, Chow LC, Tsaknis PJ, J. Endod., 13, 384 (1987)

[6] Sugawara A, Chow LC, Takagi S, Chohayeb H, J. Endod., 16, 162 (1990)

[7] Cho YR, Gosain AK, Clin. Plast. Surg., 31, 377 (2004)

[8] Kveton JF, Friedman CD, Constantino PD, Am. J. Otol., 16, 465 (1995)

[9] Ishikawa K, Eanes ED, J. Dent. Res., 72, 474 (1993)

[10] Liu C, Shen W, Gu Y, Hu L, J. Biomed. Mater. Res., 35, 75 (1997)

[11] Li Y, Zhang X, de Groot K, Biomaterials, 18, 737 (1997)

[12] Khairoun I, Driessens FCM, Boltong MG, Planell JA, Wenz R, Biomaterials, 20, 393 (1999)

[13] Wang X, Chen L, Xiang H, Ye J, J. Biomed. Mater. Res. Part B: Appl. Biomater., 81B, 410 (2007)

[14] Kim SS, Seo M, Chung JW, Kwon SY, Kim YS, J. Appl. Polym. Sci., 113(2), 1223 (2009)

[15] Lee HS, Kwon SY, Seo EM, Kim YH, Kim SS, Macromol. Res., 19(1), 90 (2011)

[16] Monma H, Ohta K, Takahashi S, FC Rep., 6, 475 (1988)

[17] Kurashina K, Kurita H, Hirano M, de Blieck JMA, Klein CPAT, de Groot K, J. Mater. Sci. -Mater. Med., 6, 340 (1995)

[18] Yamamoto Y, Ishikawa K, Fukao H, Sawada M, Asaoka K, Biomaterials, 16, 855 (1995)

[19] Hirotsugu H, Norio A, Kimimitsu O, Noritaka F, Hideo O, Atsushi O, Shuichi N, Takeyasu M, Biomaterials, 25, 431 (2004)

[20] Gbureck U, Barralet JE, Spatz K, Grover LM, Thull R, Biomaterials, 25, 2187 (2004)

[21] Chen GX, Li WW, Yu XM, Sun K, J. Mater. Sci., 44(3), 828 (2009)

[22] Tenhuisen KS, Brown PW, J. Mater. Sci. -Mater. Med., 5, 291 (1994)

[23] Bigi A, Boanini E, Botter R, Panzavolta S, Rubini K, Biomaterials, 23, 1849 (2002)

[24] Yubao L, Xingdong Z, de Groot K, Biomaterials, 18, 737 (1997)

[25] TenHuisen KS, Brown PW, Biomaterials, 19, 2209 (1998)

[26] Chow LC, Markovic M, Frukhtbeyn SA, Takagi S, Biomaterials, 26, 393 (2005)

[27] Fernandez E, Ginebra MP, Boltong MG, Driessens FCM, Ginebra J, De Mayer EAP, Verbeeck RMH, Planell JA, J. Biomed. Mater. Res., 32, 367 (1996)

[28] Park JB, Biomaterials Science and Engineering, Plenum, New York, 1984.