화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.19, No.5, 1600-1605, September, 2013
DOI10.1016/j.jiec.2013.01.029  Export Citation
Green synthesis of anisotropic silver nanoparticles and its potential cytotoxicity in human breast cancer cells (MCF-7)
Sangiliyandi Gurunathan†, Jae Woong Han, Ahmed Abdal Dayem, Vasuki Eppakayala, Jung Hyun Park, Ssang-Goo Cho, Kyung Jin Lee1, and Jin-Hoi Kim†
  • Department of Animal Biotechnology, Konkuk University, 1 Hwayang-Dong, Gwangin-gu, Seoul 143-701, South Korea
  • 1Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea
E-mail:,
We described a green, cost effective and rapid method for synthesizing anisotropic AgNPs using a novel bacterium called Escherichia fergusoni. Furthermore, synthesized AgNPs were characterized by various analytical techniques. The present study demonstrates the efficiency of biologically synthesized AgNPs as a cytotoxic agent against MCF-7 cells and also this study investigates possible molecular mechanisms underlying the cytotoxic effects of AgNPs. AgNPs showed dose dependent cytotoxicity against MCF-7 cells through activation of the lactate dehydrogenase (LDH), reactive oxygen species (ROS) generation and eventually leading to induction of apoptosis which was further confirmed through resulting nuclear fragmentation.
Keywords:E. fergusoni;Silver nanoparticles;Characterization;LDH;ROS;DNA fragmentation
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