A guaranteed cost control scheme is proposed for batch processes described by a two-dimensional (2-D) system with uncertainties and interval time-varying delay. First, a 2-D controller, which includes a robust feedback control to ensure performances over time and an iterative learning control to improve the tracking performance from cycle to cycle, is formulated. The guaranteed cost law concept of the proposed 2-D controller is then introduced. Subsequently, by introducing the LyapunovKrasovskii function and adding a differential inequality to the Lyapunov function for the 2-D system, sufficient conditions for the existence of the robust guaranteed cost controller are derived in terms of matrix inequalities. A design procedure for the controller is also presented. Furthermore, a convex optimization problem with linear matrix inequality (LMI) constraints is formulated to design the optimal guaranteed cost controller that minimizes the upper bound of the closed-loop system cost. The proposed control law can stabilize the closed-loop system as well as guarantee H performance level and a cost function with upper bounds for all admissible uncertainties. The results can be easily extended to the constant delay case. Finally, an illustrative example is given to demonstrate the effectiveness and advantages of the proposed 2-D design approach. (c) 2013 American Institute of Chemical Engineers AIChE J, 59: 20332045, 2013