방사선불투과성 무기입자를 첨가한 교대배열 폴리비닐알코올 마이크로피브릴의 제조

조혜원; 차진욱; 한성수; 이준석; 오태환; Hye Won Jo; Jin Wook Cha; Sung Soo Han; Joon Seok Lee; Tae Hwan Oh

Polymer(Korea), Vol.37, No.5, 563-570, September, 2013

Export Citation

방사선불투과성 무기입자를 첨가한 교대배열 폴리비닐알코올 마이크로피브릴의 제조

Preparation of Syndiotactic Poly(vinyl alcohol) Microfibrils with Radiopaque Inorganic Particles

조혜원, 차진욱, 한성수, 이준석¹, 오태환^†

영남대학교 나노메디컬유기재료공학과
¹영남대학교 융합섬유공학과

Hye Won Jo, Jin Wook Cha, Sung Soo Han, Joon Seok Lee¹, and Tae Hwan Oh^†

Department of Nano, Medical and Polymer Materials, Yeungnam University, Gyeongsan 712-749, Korea
¹Department of Textile Engineering and Technology, Yeungnam University, Gyeongsan 712-749, Korea

E-mail:

초록

폴리비닐알코올(poly(vinyl alcohol), PVA) 마이크로피브릴(microfibrils)을 금속 색전코일을 대체할 수 있는 고분자 색전코일에 적용하기 위해 벌크중합으로 폴리피발산비닐(poly(vinyl pivalate), PVPi)을 제조하고 비누화 공정에서 방사공정 없이 중합도가 1100 교대배열 다이애드(diad)기 함량 60.4%인 교대배열 PVA(syndiotactic PVA, s-PVA) 마이크로피브릴을 제조하였다. 또한 별도의 조영제의 투여가 불필요한 마이크로피브릴 제조를 위해 방사선불투과성 물질인 이산화지르코늄과 황산바륨을 비누화 공정에서 첨가하여 방사성불투과성 교대배열 PVA 마이크로피브릴을 제조하였고, 무기입자 함유 s-PVA 마이크로피브릴의 computed tomography(CT) value 값 측정 결과 이산화지르코늄의 함량이 12 wt% 이상에서, 황산바륨은 6 wt% 이상에서 1000 이상의 우수한 방사선불투과성을 나타내는 것을 확인하였다.

Poly(vinyl pivalate) (PVPi) was bulk polymerized to make poly(vinyl alcohol) (PVA) microfibrils to apply for polymeric embolization coils replacing metalic coils. Then, syndiotactic PVA (s-PVA) microfibrils having number-average degree of polymerization of 1100 and s-diad content of 60.4% were prepared via saponification of the PVPi with no separate spinning process. To make s-PVA microfibrils with radiopacity, zirconium dioxide (ZrO2) and barium sulfate (BaSO4) were added into s-PVA microfibrils during saponification. The computed tomography (CT) value indicating radiopacity reached up to over 1000 when the amount of ZrO2 and BaSO4 were 12 and 6 wt%, respectively.

Keywords:s-PVA;microfibrils;radiopacity;bulk polymerization;embolic materials.

[References]

Lyoo WS, Kim BC, Ha WS, Polym. Eng. Sci., 37(7), 1259 (1997)
Lyoo WS, Ha WS, Polymer, 37(14), 3121 (1996)
Yamaura K, Mizutani I, Monma K, Tanigami T, Matsuzawa SJ, Appl. Polym. Sci., 31, 521 (1986)
Yamamoto T, Seki S, Fukae R, Sangen O, Kamachi MJ, Polym. J., 22, 567 (1990)
Yamamoto T, Yoda S, Takase H, Saso T, Sangen O, Fukae R, Kamachi M, Sato T, Fukunishi Y, Polym. J., 23, 185 (1992)
Yamamoto T, Fukae R, Saso T, Sangen O, Fukae R, Kamachi M, Sato T, Fukunishi Y, Polym. J., 24, 115 (1992)
Kerber CW, Bank WO, Horton JM, Am. J. Roentgenol., 130, 1193 (1978)
Isabelle M, Richard L, J. Neurosurg., 76, 607 (1992)
Kinoshita A, Yamada K, Ito M, Yamazaki M, Teneda M, Hayakawa T, Neuroradiology., 36, 65 (1994)
Brown KT, Brody LA, Decorato DR, Getrajdman GI, J. Vasc. Intev. Radiol., 12, 882 (2001)
Brandrup J, Immergut EH, Editors, Polymer Handbook, 3rd Edn., Wiley, New York (1989)
Lyoo WS, Ha WS, J. Polym. Sci. A: Polym. Chem., 35(1), 55 (1997)
Lyoo WS, Han SS, Kim JH, Yoon WS, Lee CJ, Kwon IC, Lee J, Ji BC, Han MH, Angew. Makromol. Chem., 271, 46 (1999)
Naito R, Kobunshi Kagaku., 15, 597 (1958)
Patel P, Rodriguez F, Moloney G, J. Appl. Polym. Sci., 23, 2335 (1979)
Grubb DT, Kearney FR, J. Appl. Polym. Sci., 39, 695 (1990)
Gurp MV, Int. J. Polym. Mater. Polym. Biomat., 22, 219 (1993)
Lyoo WS, Kim JH, Choi JH, Kim BC, Blackwell J, Macromolecules, 34(12), 3982 (2001)
Choi JH, Ko SW, Kim BC, Blackwell J, Lyoo WS, Macromolecules, 34(9), 2964 (2001)
Vladimir B, Irera B, Lilian HJ, Am. Ceram. Soc. Bull., 80, 982 (1997)
Hammer O, Maurer HJ, Polym. Composite., 19, 116 (1998)

[1] Lyoo WS, Kim BC, Ha WS, Polym. Eng. Sci., 37(7), 1259 (1997)

[2] Lyoo WS, Ha WS, Polymer, 37(14), 3121 (1996)

[3] Yamaura K, Mizutani I, Monma K, Tanigami T, Matsuzawa SJ, Appl. Polym. Sci., 31, 521 (1986)

[4] Yamamoto T, Seki S, Fukae R, Sangen O, Kamachi MJ, Polym. J., 22, 567 (1990)

[5] Yamamoto T, Yoda S, Takase H, Saso T, Sangen O, Fukae R, Kamachi M, Sato T, Fukunishi Y, Polym. J., 23, 185 (1992)

[6] Yamamoto T, Fukae R, Saso T, Sangen O, Fukae R, Kamachi M, Sato T, Fukunishi Y, Polym. J., 24, 115 (1992)

[7] Kerber CW, Bank WO, Horton JM, Am. J. Roentgenol., 130, 1193 (1978)

[8] Isabelle M, Richard L, J. Neurosurg., 76, 607 (1992)

[9] Kinoshita A, Yamada K, Ito M, Yamazaki M, Teneda M, Hayakawa T, Neuroradiology., 36, 65 (1994)

[10] Brown KT, Brody LA, Decorato DR, Getrajdman GI, J. Vasc. Intev. Radiol., 12, 882 (2001)

[11] Brandrup J, Immergut EH, Editors, Polymer Handbook, 3rd Edn., Wiley, New York (1989)

[12] Lyoo WS, Ha WS, J. Polym. Sci. A: Polym. Chem., 35(1), 55 (1997)

[13] Lyoo WS, Han SS, Kim JH, Yoon WS, Lee CJ, Kwon IC, Lee J, Ji BC, Han MH, Angew. Makromol. Chem., 271, 46 (1999)

[14] Naito R, Kobunshi Kagaku., 15, 597 (1958)

[15] Patel P, Rodriguez F, Moloney G, J. Appl. Polym. Sci., 23, 2335 (1979)

[16] Grubb DT, Kearney FR, J. Appl. Polym. Sci., 39, 695 (1990)

[17] Gurp MV, Int. J. Polym. Mater. Polym. Biomat., 22, 219 (1993)

[18] Lyoo WS, Kim JH, Choi JH, Kim BC, Blackwell J, Macromolecules, 34(12), 3982 (2001)

[19] Choi JH, Ko SW, Kim BC, Blackwell J, Lyoo WS, Macromolecules, 34(9), 2964 (2001)

[20] Vladimir B, Irera B, Lilian HJ, Am. Ceram. Soc. Bull., 80, 982 (1997)

[21] Hammer O, Maurer HJ, Polym. Composite., 19, 116 (1998)