The vapor-liquid equilibrium at 101.3 kPa has been determined for the binary systems methyl ethanoate + oxolane (tetrahydrofuran) and oxolane + toluene. The binary system methyl ethanoate + oxolane exhibits positive deviations from ideal behavior, while the binary system oxolane + toluene presents moderate negative deviations from ideality. No azeotropes are present. The activity coefficients and boiling point of the solution were correlated with its composition by the Redlich-Kister, Wohl, Wilson, UNIQUAC, NRTL, and Wisniak-Tamir equations.