Isothermal vapor-liquid equilibrium data are presented for the ethane (R170) + perfluoropropane (R218) binary system. Measurements were performed at five isotherms ranging from (264.05 to 308.04) K, with pressure ranging from (0.298 to 4.600) MPa. The measurements were undertaken using a "static-analytic" type apparatus, with sampling of the equilibrium phases via a mobile capillary sampler (ROLSI). The uncertainties in the measurements were within 0.06 K, 0.9 kPa, and less than 0.006 for temperature, pressure, and mole fraction, respectively. The full set of isothermal vapor-liquid equilibrium data was successfully correlated with the Peng-Robinson equation of state, incorporating the Mathias-Copeman alpha function, and the Wong-Sandler mixing rule with the Non-Random Two-Liquid (NRTL) activity coefficient model.