The solubilities of 1,3,2-dioxaphosphorinane-2-methanol-a,alpha-5,5-tetramethyl 2-oxide (DMTO) were measured in different solvents including ethyl acetate, methanol, ethanol, chloroform, acetonitrile, acetone, 1,2-dichloroethane, and water at temperature ranging from 278.15 K to 343.15 K by the gravimetrical method. The structure of DMTO was characterized by nuclear magnetic resonance (H-1 NMR and P-13 NMR), infrared spectroscopy (IR), and mass spectroscopy (MS). The thermal stability of DMTO was characterized by thermogravimetric analysis (TGA). The modified Apelblat was used to correlate the measured solubility data. The results showed that the calculated solubilities were in good agreement with experimental values in all selected solvents. The root-mean-square deviation was less than 0.091 %, and the average relative error was less than 0.22 % in all of the experiments.