Oxidative dehydrogenation of propane using Ni-Mo-based metal oxide catalysts ( without or with dopants: zinc and boron) was investigated in this paper. The catalysts were prepared, tested, and characterized by BET, SEM, XRD, and FTIR techniques. Higher propylene yields were obtained with alumina-supported catalysts compared to silica-supported ones, which showed much higher selectivity when doped with boron at lower propane conversions. Propylene yield was found to increase with increasing reaction temperatures and/or decreasing propane-to-oxygen ratios due to the increase in propane conversion.