Catalysts or support to catalysts based on layered double hydroxides (LDHs) have been widely investigated in the last few years. Supported Au nanoparticles (NPs), prepared typically by a homogeneous deposition-precipitation technique, have been utilized as catalysts with high activity and selectivity for styrene epoxidation. We herein present a preparation of chemically reduced and cost-saving Ag NPs on the LDH support used as catalyst for styrene epoxidation. A proper reaction condition is optimized, for example, a loading of 2.67 wt% Ag, a conversion temperature of 82 A degrees C, and a conversion time of 8 h. The Ag/LDH catalyst exhibits enhanced reaction selectivity and product yield in comparison with the Au/LDH reported previously. Our results may initiate a facile framework appropriate for noble metallic NPs supported on layered inorganic crystal compounds.