Ether mixtures containing oxygen in their body such as 2-methoxy-2-methylbutane (tert-amyl methyl ether; TAME) and 2-methoxy-2-methylpropane (methyl tert-butyl ether; MTBE) are used as octane boosters for lead-free or low-leaded gasoline because of their octane-enhancing and pollution-reducing capabilities. In this work, isothermal vapor-liquid equilibrium was measured by headspace gas chromatography, one of the static methods, for TAME + n-alcohol (C-1-C-4) binary mixtures at 323.15 and 333.15 K. The binaries showed positive deviations from Raoult’s law and have minimum boiling azeotropes, except for TAME + l-butanol. Results were correlated with GE model equations and also compared with the values predicted by modified UNIFAC (Dortmund).