Several types of experiments are performed in laboratories at Fauske & Associates, LLC (FAI). Test equipment includes calorimeters to characterize reactive chemical systems and multiple instruments to characterize both combustible dust and gas/vapor explosions. It is a challenge to ensure that each project is completed safely, since a variety of chemicals are used and tested under extreme conditions. It is vital to ensure the safety of people, property, and the environment at all times. This requires first identifying the hazards (including rigorous review of material safety data sheets) and then implementing adequate engineering and administrative controls as necessary. This article will document best practices including management commitment, predicting and eliminating hazards during extreme test conditions, and implementing inherently safer design concepts to laboratory testing. (c) 2013 American Institute of Chemical Engineers Process Saf Prog, 2013