약물을 담지한 Poly(Acrylamide-co-PEG)Microgel 약물방출 특성

조석형; 김공수; 이영우; 김영준

Journal of the Korean Industrial and Engineering Chemistry, Vol.6, No.1, 42-48, February, 1995

Export Citation

약물을 담지한 Poly(Acrylamide-co-PEG)Microgel 약물방출 특성

Drug Release from Drug Loading Poly(Acrylamide-co-PEG) Microgels

조석형, 김공수, 이영우, 김영준

초록

Poly(acrylamide-co-PEG) microgel은 침전중합에 의하여 에탄올 중에서 제조되었으며 가교제의 농도 및 acryloyl terminated poly(ethylene glycol) macromonomer(AtPEGM)의 농도에 따라 입자의 크기가 다른 microgel을 얻을 수 있었다. 이 시스템에서 AtPEGM이 중합의 안정제로 작용함을 알 수 있고 따라서 균일한 크기를 갖는 미립자를 제조할 수 있으며 그 morphology는 core-corona형이었다. 또한 염의 농도에 영향을 받지 않고 물에서의 분산안정성이 우수하였으며, 약물방출시스템에 사용하였을 때 가교도와 약물의 성질에 따라 약물방출속도가 조절되지만 매우 빠른 방출속도를 보였다.

Precipitation polymerization of acrylamide( AAm) and acryloyl terminated poly(ethylene glycol)macromonomer(AtPEGM) was carried out in ethanol. Different size of microgels were obtained by changing the mole ratio of AtPEG macromonomer and N, N' - methylene- bis- acrylamide(MBAAm). The microgels were stabilized by steric stabilization of AtPEG macromonomer and monodisperse microgels have the morphology of core-corona type with the size distribution of submicron. The microgels were good water dispersable and stable in KCI solution. The drug release rate from microgel particls depended on crosslinking density aud hydrophilicity of drug and was very fast.

[References]

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[1] Kawaguchi H, Amagasa H, Hagiya T, Ohtosuka Y, Colloids Surf., 13, 295 (1985)

[2] Obrecht W, Seitz U, Fanke W, Makromol. Chem., 175, 3587 (1874)

[3] Obrecht W, Seitz U, Fanke W, Makromol. Chem., 177, 1877 (1976)

[4] Eda Y, Mitani K, 高分子論文集, 47, 667 (1990)

[5] Hayashi S, Komatsu A, Hirai T, J. Polym. Sci. A: Polym. Chem., 27, 157 (1989)

[6] Sundardi F, Zubir A, Sabarinah Y, Sofiarti W, J. Macromol. Sci.-Chem., A24, 1369 (1987)

[7] Candau F, Leong YS, J. Polym. Sci. A: Polym. Chem., 223, 193 (1985)

[8] Bade W, Reichert KH, Eur. Polym. J., 20, 505 (1984)

[9] Plton RF, Colloids Surf., 20, 247 (1986)

[10] Tai EF, J. Polym. Sci. A: Polym. Chem., 24, 567 (1986)

[11] Kawaguchi H, Kawahara M, Yaguchi N, Hoshino F, Ohtsuka Y, Polym. J., 20, 903 (1988)

[12] Kawaguchi H, Yamada Y, Kataoka S, Morita Y, Ohtsuka Y, Polym. J., 23, 955 (1991)

[13] Anderson JM, Kim SW, "Advances in Drug Delivery System," Vol. 1-4 (1989)

[14] Peppas NA, "Hydrogels in Modicine and Pharmacy," 1-4, CRC Press, Inc. Boca Raton Florida (1987)

[15] Kim KS, Cho SH, Kim YJ, Polym. J., 25, 847 (1993)

[16] Paine AJ, J. Polym. Sci. A: Polym. Chem., 28, 2485 (1990)

[17] Seki T, Gawaguchi T, Endoh H, Ishigawa K, Juni K, Nakano M, J. Pharm. Sci., 79, 985 (1990)