Amphiphilic antidepressant drug amitriptyline hydrochloride under the influence of ionic and nonionic hydrotropes; micellization and phase separation

Malik Abdul Rub; Abdullah M. Asiri; Naved Azum; Anish Khan; Aftab Aslam Parwaz Khan; Sher Bahadar Khan; Mohammed M. Rahman; Kabir-ud-Din

Journal of Industrial and Engineering Chemistry, Vol.19, No.6, 1774-1780, November, 2013

DOI10.1016/j.jiec.2013.02.019 Export Citation

Amphiphilic antidepressant drug amitriptyline hydrochloride under the influence of ionic and nonionic hydrotropes; micellization and phase separation

Malik Abdul Rub^{1, 2, †}, Abdullah M. Asiri^{1, 2}, Naved Azum^{1, 2}, Anish Khan^{1, 2}, Aftab Aslam Parwaz Khan^{1, 2}, Sher Bahadar Khan^{1, 2}, Mohammed M. Rahman^{1, 2}, and Kabir-ud-Din³

¹Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia
²Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
³Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India

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Herein we report the micellization and cloud point of an amitriptyline hydrochloride (AMT) under the influence of cationic, anionic and nonionic hydrotropes. Anionic hydrotropes were employed to know the micellar and surface behaviors, besides studying the clouding behavior of AMT drug with cationic, anionic and nonionic hydrotropes. Tensiometric study has been performed and the properties studied include the critical micelle concentration (cmc), maximum surface excess at the air/water interface (Gmax), the minimum area per of amphiphilic molecule at air/water interface (Amin), and the different thermodynamic parameters, besides clouding phenomenon. Interaction parameters of micelles (βm) and monolayer (βσ) indicate that drug-hydrotrope systems show better interaction at the interface than in micelles.

Keywords:Amitriptyline hydrochloride (AMT);Critical micelle concentration (cmc);Surface tension;Hydrotropes;Thermodynamic parameter

[References]

Neuberg C, Biochemische Zeitschrift., 76, 107 (1916)
Balasubramanian D, Friberg SE, in: Matijevic E (Ed.), Surface and Colloid Science, Plenum Press, New York (1993)
Srivastava RC, Nagappa AN, Surface Activity in Drug Action, Amsterdam, The Netherlands (2005)
Sarmiento F, Lopez-Fontan JL, Prieto V, Attwood D, Mosquera V, Colloid and Polymer Science., 27, 1144 (1997)
Taboada P, Attwood D, Ruso JM, Garcia M, Mosquera V, Physical Chemistry Chemical Physics., 2, 5175 (2000)
Attwood D, Advances in Colloid and Interface Science., 55, 271 (1995)
Clint JH, Journal of the Chemical Society, Faraday Transactions., 251, 1327 (1975)
Holland PM, Rubingh DN, Journal of Physical Chemistry., 87, 1984 (1983)
Rosen MJ, Hua XY, Journal of Colloid and Interface Science., 86, 164 (1982)
Motomura K, Arantono M, Ogino K, Abe M, in: Ogino K, Abe M (Eds.), Mixed Surfactant Systems, Dekker, New York (1993)
Kabir-ud-Din, Rub MA, Naqvi AZ, J. Phys. Chem. B, 114(19), 6354 (2010)
Kabir-ud-Din, Rub MA, Naqvi AZ, J. Colloid Interface Sci., 354(2), 700 (2011)
Alam MS, Naqvi AZ, Kabir-ud-Din, Colloids and Surfaces B., 57, 204 (2007)
Kabir-ud-Din, Rub A, Sheikh MS, J. Chem. Eng. Data, 55(12), 5642 (2010)
Kabir-ud-Din, Rub MA, Naqvi AZ, J. Chem. Eng. Data, 56(7), 3115 (2011)
De S, Aswal VK, Goyal PS, Bhattacharya S, J. Phys. Chem., 100(28), 11664 (1996)
Britton HTS, third ed., Hydrogen Ions. Their Determination and Importance in Pure and Industrial Chemistry, vol. 2, Chapman, London (1942)
Attwood D, Florence AT, Surfactant Systems. Their Chemistry, Pharmacy and Biology, Chapman and Hall, New York (1983)
Khan IA, Khanam AJ, Khan ZA, Kabir-ud-Din, J. Chem. Eng. Data, 55(11), 4775 (2010)
Zhou Q, Rosen MJ, Langmuir, 19(11), 4555 (2003)
Zana R, Langmuir, 12(5), 1208 (1996)
Mukerjee P, Advances in Colloid and Interface Science., 1, 242 (1967)
Sugihara G, Miyazono AM, Nagadome S, Oida T, Hayashi Y, Ko JS, Journal of Oleo Science., 52, 449 (2003)
Schott H, Royce AE, Journal of Pharmaceutical Sciences., 73, 793 (1984)
Valaulikar BS, Manohar CJ, Journal of Colloid and Interface Science., 108, 403 (1985)
Zulauf M, Weckstrom K, Hayter JB, Degiorgio V, Corti M, Journal of Physical Chemistry., 89, 3411 (1985)
Gu T, Galera-Gomez PA, Colloids and Surfaces A., 104, 307 (1995)
Katzung BG, Basic and Clinical Pharmacology, ninth ed., McGraw Hill, New York (2004)
Alam MS, Kabir-ud-Din, Mandal AB, Journal of Dispersion Science and Technology., 31, 1721 (2010)
Naqvi AZ, Rub MA, Kabir-ud-Din, J. Colloid Interface Sci., 361(1), 42 (2011)
Rub MA, Asiri AM, Sheikh MS, Khan A, Khan AAP, Azum N, Kabir-ud-Din, Journal of Molecular Liquids., 172, 59 (2012)

[Referenced By]

[1] Neuberg C, Biochemische Zeitschrift., 76, 107 (1916)

[2] Balasubramanian D, Friberg SE, in: Matijevic E (Ed.), Surface and Colloid Science, Plenum Press, New York (1993)

[3] Srivastava RC, Nagappa AN, Surface Activity in Drug Action, Amsterdam, The Netherlands (2005)

[4] Sarmiento F, Lopez-Fontan JL, Prieto V, Attwood D, Mosquera V, Colloid and Polymer Science., 27, 1144 (1997)

[5] Taboada P, Attwood D, Ruso JM, Garcia M, Mosquera V, Physical Chemistry Chemical Physics., 2, 5175 (2000)

[6] Attwood D, Advances in Colloid and Interface Science., 55, 271 (1995)

[7] Clint JH, Journal of the Chemical Society, Faraday Transactions., 251, 1327 (1975)

[8] Holland PM, Rubingh DN, Journal of Physical Chemistry., 87, 1984 (1983)

[9] Rosen MJ, Hua XY, Journal of Colloid and Interface Science., 86, 164 (1982)

[10] Motomura K, Arantono M, Ogino K, Abe M, in: Ogino K, Abe M (Eds.), Mixed Surfactant Systems, Dekker, New York (1993)

[11] Kabir-ud-Din, Rub MA, Naqvi AZ, J. Phys. Chem. B, 114(19), 6354 (2010)

[12] Kabir-ud-Din, Rub MA, Naqvi AZ, J. Colloid Interface Sci., 354(2), 700 (2011)

[13] Alam MS, Naqvi AZ, Kabir-ud-Din, Colloids and Surfaces B., 57, 204 (2007)

[14] Kabir-ud-Din, Rub A, Sheikh MS, J. Chem. Eng. Data, 55(12), 5642 (2010)

[15] Kabir-ud-Din, Rub MA, Naqvi AZ, J. Chem. Eng. Data, 56(7), 3115 (2011)

[16] De S, Aswal VK, Goyal PS, Bhattacharya S, J. Phys. Chem., 100(28), 11664 (1996)

[17] Britton HTS, third ed., Hydrogen Ions. Their Determination and Importance in Pure and Industrial Chemistry, vol. 2, Chapman, London (1942)

[18] Attwood D, Florence AT, Surfactant Systems. Their Chemistry, Pharmacy and Biology, Chapman and Hall, New York (1983)

[19] Khan IA, Khanam AJ, Khan ZA, Kabir-ud-Din, J. Chem. Eng. Data, 55(11), 4775 (2010)

[20] Zhou Q, Rosen MJ, Langmuir, 19(11), 4555 (2003)

[21] Zana R, Langmuir, 12(5), 1208 (1996)

[22] Mukerjee P, Advances in Colloid and Interface Science., 1, 242 (1967)

[23] Sugihara G, Miyazono AM, Nagadome S, Oida T, Hayashi Y, Ko JS, Journal of Oleo Science., 52, 449 (2003)

[24] Schott H, Royce AE, Journal of Pharmaceutical Sciences., 73, 793 (1984)

[25] Valaulikar BS, Manohar CJ, Journal of Colloid and Interface Science., 108, 403 (1985)

[26] Zulauf M, Weckstrom K, Hayter JB, Degiorgio V, Corti M, Journal of Physical Chemistry., 89, 3411 (1985)

[27] Gu T, Galera-Gomez PA, Colloids and Surfaces A., 104, 307 (1995)

[28] Katzung BG, Basic and Clinical Pharmacology, ninth ed., McGraw Hill, New York (2004)

[29] Alam MS, Kabir-ud-Din, Mandal AB, Journal of Dispersion Science and Technology., 31, 1721 (2010)

[30] Naqvi AZ, Rub MA, Kabir-ud-Din, J. Colloid Interface Sci., 361(1), 42 (2011)

[31] Rub MA, Asiri AM, Sheikh MS, Khan A, Khan AAP, Azum N, Kabir-ud-Din, Journal of Molecular Liquids., 172, 59 (2012)