용액 농도에 따른 항균성 알긴산 아연 필름의 제조 및 그 특성

이주현; 서혜진; 손태원; 임학상; Ju-Hyun Lee; Hye-Jin Seo; Tae-Won Son; Hak-Sang Lim

Polymer(Korea), Vol.37, No.6, 677-684, November, 2013

Export Citation

용액 농도에 따른 항균성 알긴산 아연 필름의 제조 및 그 특성

Preparation and Properties of Antimicrobial Zinc Alginate Films according to Solution Concentration

이주현, 서혜진, 손태원¹, 임학상^{2, †}

영남대학교 유기신소재공학과
¹영남대학교 나노메디컬유기재료공학과
²세명대학교 바이오환경공학과

Ju-Hyun Lee, Hye-Jin Seo, Tae-Won Son¹, and Hak-Sang Lim^{2, †}

Department of Advanced Organic Materials, Yeungnam University, Gyeongsan 712-749, Korea
¹Department of Nano, Medical &Polymer Materials, Yeungnam University, Gyeongsan 712-749, Korea
²Department of Biological &Environmental Engineering, Semyung University, Jecheon 390-711, Korea

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초록

Alginate를 농도 별로 용액상태로 제조한 후 필름 메이커를 이용하여 필름 형태로 만든 후 3 wt%의 ZnCl2 수용액에 필름을 고화시킨 후 수세하여 60 ℃의 건조기에서 약 20분 동안 건조시켜 zinc alginate 필름을 제조하였다. 필름의 특성을 조사하기 위하여 항균성 및 점도와 FTIR, TGA, SEM, EDS 및 접촉각, 인장측정, 용해도분석 등을 측정하였다. 항균성 시험 결과, zinc alginate 필름에서는 두 균주(포도상구균, 폐렴간균) 모두 우수한 항균력이 나타나는 것을 확인하였다. 9 wt%의 sodium alginate로 제조한 zinc alginate 필름의 표면은 다른 농도별 필름보다 균일한 형태를 나타내었으며, ZnCl2 응고액에 잘 고화될 때 단단하고 거친 느낌의 단면 형태를 확인하였다. Zinc alginate 필름의 인장강도는 가교결합에 의해 sodium alginate 용액의 농도가 증가함에 따라 증가하였으며, 초기 열 분해 온도가 점차적으로 높아지고 있는 형태를 보였다.

Zinc alginate films were prepared by a film maker from sodium alginate solutions of different weight ratios and then they solidified into 3 wt% content ZnCl2 coagulation solution and washed and dried at a 60 ℃ oven for 20 min. The characteristics were measured by several methods (antimicrobial activity, viscosity, FTIR, TGA, SEM, EDS, contact angle, tensile strength and solubility) and the film properties were investigated. The antimicrobial test showed that the zinc alginate films result in excellent antimicrobial activity in the two strains (Klebsiella pneumonia, Staphylococcus). The surface of zinc alginate film from the solution of 9 wt% sodium alginate showed more uniform shape than any other films and the cross-section were hard and rough when the films were well-solidified by the ZnCl2 solution. The tensile strength of zinc alginate films increased along with the concentration of sodium alginate solution due to the cross-linking, and the initial thermal decomposition temperature increased gradually.

Keywords:zinc alginate films;sodium alginate;solution concentration;antimicrobial activity.

[References]

Lee HS, Suh JH, Korean J. Biotechnol. Bioen., 17, 63 (2002)
Ha SH, Rhim JW, Kim BY, Baik MY, J. Korean Soc.Appl. Biol. Chem., 50, 111 (2007)
Han SM, Nam CW, Ko SW, J. Korean Fiber Soc., 37, 365 (2000)
Qin YM, Hu HQ, Luo AX, J. Appl. Polym. Sci., 101(6), 4216 (2006)
Qin YM, J. Appl. Polym. Sci., 91(3), 1641 (2004)
Son TW, Lee MG, Han SJ, Text. Color. Finish., 23, 391 (2011)
Son TW, Lee JH, Lee MK, Cho JW, Text. Color.Finish., 23, 201 (2011)
Rhim JW, Kim JH, Korean J. Food Sci. Technol., 36, 69 (2004)
Chan LW, Jin Y, Heng PWS, Int. J. Pharmaceut., 242, 255 (2002)
Teresa M, Dorota WC, Fibers Text. East. Eur., 13, 35 (2005)
Rhim JW, Kim JH, Kim DH, Korean J. Food Sci.Technol., 35, 217 (2003)
Lee BH, Lee SB, Kim WG, Fiber Technology and Industry., 13, 21 (2009)
Haug A, Larsen B, Smidsrod O, Acta Chem., 21, 691 (1967)
Haug A, Larsen B, Acta Chem., 16, 1908 (1962)
Penman A, Sanderson GR, Carbohydr. Res., 25, 273 (1972)
Grasdalen H, Carbohydr. Res., 118, 255 (1983)
Larsen B, Smidsrod O, Painter T, Haug A, Acta Chem., 24, 726 (1970)
Kuo CK, Ma PX, Biomaterials., 22, 511 (2001)
van Susante JL, Buma P, van Osch GJ, Versleyen D, van der Kraan PM, van der Berg WB, Homminga GN, Acta Orthop., 66, 549 (1995)
Yoon MO, Lee SC, Rhim JW, Kim JM, J. Korean Soc. Food Sci. Nutr., 33, 747 (2004)
Rhim JW, Lebensm Wiss Technol., 37, 323 (2004)
Gilchrist T, Martin AM, Biomaterials., 4, 317 (1983)
Yokoyama F, Achife EC, Matsuoka M, Shimamura Y, Monobe K, Polymer., 32, 1916 (1991)
Rhim JW, Kim JH, Kim DH, J. Korean Food Sci.Technol., 35, 271 (2003)
Zeng MF, Fang ZP, Xu CW, J. Membr. Sci., 230(1-2), 175 (2004)
Jin J, Song M, Hourston DJ, Biomacromolecules., 5, 162 (2000)

[Referenced By]

[1] Lee HS, Suh JH, Korean J. Biotechnol. Bioen., 17, 63 (2002)

[2] Ha SH, Rhim JW, Kim BY, Baik MY, J. Korean Soc.Appl. Biol. Chem., 50, 111 (2007)

[3] Han SM, Nam CW, Ko SW, J. Korean Fiber Soc., 37, 365 (2000)

[4] Qin YM, Hu HQ, Luo AX, J. Appl. Polym. Sci., 101(6), 4216 (2006)

[5] Qin YM, J. Appl. Polym. Sci., 91(3), 1641 (2004)

[6] Son TW, Lee MG, Han SJ, Text. Color. Finish., 23, 391 (2011)

[7] Son TW, Lee JH, Lee MK, Cho JW, Text. Color.Finish., 23, 201 (2011)

[8] Rhim JW, Kim JH, Korean J. Food Sci. Technol., 36, 69 (2004)

[9] Chan LW, Jin Y, Heng PWS, Int. J. Pharmaceut., 242, 255 (2002)

[10] Teresa M, Dorota WC, Fibers Text. East. Eur., 13, 35 (2005)

[11] Rhim JW, Kim JH, Kim DH, Korean J. Food Sci.Technol., 35, 217 (2003)

[12] Lee BH, Lee SB, Kim WG, Fiber Technology and Industry., 13, 21 (2009)

[13] Haug A, Larsen B, Smidsrod O, Acta Chem., 21, 691 (1967)

[14] Haug A, Larsen B, Acta Chem., 16, 1908 (1962)

[15] Penman A, Sanderson GR, Carbohydr. Res., 25, 273 (1972)

[16] Grasdalen H, Carbohydr. Res., 118, 255 (1983)

[17] Larsen B, Smidsrod O, Painter T, Haug A, Acta Chem., 24, 726 (1970)

[18] Kuo CK, Ma PX, Biomaterials., 22, 511 (2001)

[19] van Susante JL, Buma P, van Osch GJ, Versleyen D, van der Kraan PM, van der Berg WB, Homminga GN, Acta Orthop., 66, 549 (1995)

[20] Yoon MO, Lee SC, Rhim JW, Kim JM, J. Korean Soc. Food Sci. Nutr., 33, 747 (2004)

[21] Rhim JW, Lebensm Wiss Technol., 37, 323 (2004)

[22] Gilchrist T, Martin AM, Biomaterials., 4, 317 (1983)

[23] Yokoyama F, Achife EC, Matsuoka M, Shimamura Y, Monobe K, Polymer., 32, 1916 (1991)

[24] Rhim JW, Kim JH, Kim DH, J. Korean Food Sci.Technol., 35, 271 (2003)

[25] Zeng MF, Fang ZP, Xu CW, J. Membr. Sci., 230(1-2), 175 (2004)

[26] Jin J, Song M, Hourston DJ, Biomacromolecules., 5, 162 (2000)