Chemistry Letters, Vol.42, No.10, 1294-1296, 2013
Asymmetric Formal [3+2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol-mediated Domino Aldol-Acetalization Reaction for the Construction of Tetrahydrofuran
Highly enantioselective synthesis of tetrahydrofurans was accomplished via a formal [3 + 2] cycloaddition reaction of succinaldehyde, which acts as a three-carbon unit. The reaction consists of the domino reaction of the diarylprolinol-mediated aldol reaction of succinaldehyde followed by an intramolecular acetalization reaction.