Copper is well known as a classical transition metal used in heterogeneous catalysis. In this study, copper-loaded apatitic calcium phosphates were prepared using incipient wetness impregnation (IWI) and ionic exchange (IE) methods. The interaction between copper precursor (copper nitrate trihydrate, Cu(NO3)(2).3H(2)O) and apatitic calcium phosphate (CaP) depended strongly on the preparation method and the content of copper-loaded. Using IE, copper(II) cations (Cu2+) were incorporated in the apatitic structure of CaP. The content of copper(II) cations seemed to be limited at about 2.2wt.%. Calcination at 400 degrees C had no influence on the solids obtained by the IE method. Using IWI, the deposition of a theoretical copper content of 2wt.% led to the incorporation of copper(II) cations in the apatitic structure of CaP by IE with Ca2+, despite the low quantity of aqueous solvent used. Therefore the resulting product was similar to that obtained by IE. When the theoretical copper content rose to 20wt.%, the entire amount of copper precursor molecules were largely deposited, which resulted in the formation of copper oxide particles (CuO) after air calcination at 400 degrees C. Thermo-mechanical analysis study showed that the presence of copper oxide did not modify the thermal shrinkage of the initial calcium phosphate. On the other hand, thermal shrinkage was much more important in the case of CaP substituted with copper(II) cations.