The unsteady laminar natural convection in an inclined square enclosure with heat-generating porous medium whose heat varies by a cosine function is investigated by a thermal equilibrium model and the Brinkman-Darcy-Forchheimer model numerically, with the four cooled walls of closure as isothermal. The numerical code based on the finite-volume method has been validated by reference data before it was adopted. Influence of dimensionless frequency and inclination angle on heat transfer characteristics in a square enclosure, such as flow distribution, isotherm, averaged Nusselt number on each wall, and time-averaged Nusselt number, are discussed, with specified value for Rayleigh number = 10(8), Darcy number = 10(-4), Prandtl number = 7, porosity = 0.4, and specific heat ratio = 1. It is found that when the internal heat source varies by cosine, the Nusselt numbers of the four walls oscillate with the same frequency as the internal heat source; however, phase difference occurs. Moreover, frequency has little impact on time-averaged Nusselt number of the four walls, which is different from the phenomenon discovered in natural convection with suitable periodic varying wall temperature boundary condition. Moreover, inclination angle plays an important role in the heat transfer characteristics of the walls studied.