Waterborne polyurethane (WBPU) adhesives were prepared using poly(tetramethylene oxide glycol), 4,4'-dicyclohexylmethane diisocyanate (H12MDI), hydrophilic agent dimethylol propionic acid and chain extender of 2,2,3,3-tetrafluoro-1,4-butanediol (TFBD), ethylene diamine (EDA), and 1,4-butanediol. All three chain extenders have been used as single and mixed (different ratio) content during synthesis, and the effect of chain extender and their content to the properties of tensile strength, Young's modulus, water swelling (%), and adhesive strength was investigated. The adhesive strength value was higher using EDA as a single-chain extender; however, the potentiality of adhesive strength under water was improved using mixed-chain extenders of EDA and TFBD in WBPU adhesives. The maxima potentiality was observed with 6.31 mole% TFBD and 2.10 mole% EDA in WBPU adhesives.