Multiwalled carbon nanotube and ionic liquid-modified carbon ceramic electrode (MWCNT-IL|CCE) was employed for the simultaneous determination of diclofenac and indomethacin (IND). The measurements were carried out by differential pulse voltammetry method in optimal conditions. The prepared electrode showed appropriate voltammetric responses to DCF and IND with 0.225 V difference in the oxidation peak potentials, making fabricated electrode suitable for simultaneous determination of these compounds. The calibration curves were linear over a wide range of concentrations of each species including 0.05-50 mu mol L-1 for DCF and 1-50 mu mol L-1 for IND. Detection limits were found to be 18 and 260 nM for DCF and IND, respectively. The developed method having good stability and sensitivity was successfully applied for DCF and IND in commercial tablet as well as human blood plasma samples.