The solubility of 2,2',6,6'-tetrabromo-4,4'-isopropylidene phenol (TBBPA) in pure water, calcium chloride (CaCl2) + water and different surfactants (hexadecyltrimethylammonium bromide (CTAB), 1-hexadecylpyridinium chloride (CPC), sodium dodecylbenzenesulfonate (SDBS) and dodecyl sodium sulfate (SDS)) + water has been determined at (293.2, 298.2, 303.2, 308.2) K by the static equilibrium method. The solubility of TBBPA was determined by high performance liquid chromatography (HPLC). The relative standard deviations of the solubility data are all less than 2.6%.