A nanostructured silver-aniline modified pencil electrode obtained by applying experimental design and optimization was developed for the differential pulse stripping voltammetric quantification of acetaminophen in the pharmaceutical products, tablet and syrup. The electrode development process was performed by the modification of PGE with aniline using CV procedure and the reduction of silver nanoparticle on the polyaniline modified PGE. As a result, a new electrode system consisting of a nanostructured silver-polyaniline modified pencil graphite electrode (AgNS-PA-PGE) was obtained to reach a well-defined and higher peak current for the analysis of the related drug. The calibration curve was found linear in the range of 5 x 10(-8)-8 x 10(-7) M for acetaminophen. The validity and applicability of the proposed voltammetric method was tested by analyzing independent validation samples. It was observed that the proposed voltammetric approach for the real tablet and syrup samples gave successful analysis results. (C) 2013 The Electrochemical Society. All rights reserved.