A dynamic mass transfer model, coupled with transient back transport flux for a Rotating Disk-Membrane (RDM) module has been developed in the present study. The simulation algorithm is capable of predicting the permeate flux (J), membrane surface concentration (c(m)), and permeate concentration (c(p)) under different parametric conditions of transmembrane pressure (TMP), feed concentration (c(0)), stirrer speed ((2)), and membrane speed of rotation ((1)). The key feature of the proposed model is the analytical solution of the governing component balance equation. Additionally, the well-known osmotic pressure model and the Spiengler-Kedem black box model were used to describe the solvent transport through membrane. The proposed model was validated with the experimental results obtained in ultrafiltration of bovine serum albumin (BSA)/water solution conducted in a standard RDM module, fitted with polyethersulphone (PES) membrane of 30kDa molecular weight cut-off (MWCO). The maximum absolute deviation of the model predictions with respect to the experimental results was observed to be well within 5%.