새로운 고분자 의약품의 합성에 관한 연구(IV)-Polyacryloylsulfadiazine의 합성과 항균활성-

김선일; 나재운

Journal of the Korean Industrial and Engineering Chemistry, Vol.6, No.5, 917-922, October, 1995

Export Citation

새로운 고분자 의약품의 합성에 관한 연구(IV)-Polyacryloylsulfadiazine의 합성과 항균활성-

Synthesis of New Polymeric Medicinal Agents(Ⅳ) -Synthesis and Antimicrobial Activity of Polyacryloylsulfadiazine-

김선일, 나재운

초록

Polyacrylic acid와 sulfadiazine을 반응시키는 합성법을 검토하였으며 그 중합체약에 대한 항균활성을 측정하였다. 중합체약은 Acid Chloride법에 의하여 높은 수득률로 합성할 수 있었으나, DCC법은 수득률이 낮았다. 중합체약의 항균활성 측정은 2단계 희석법에 의한 최소발육 저지 농도로서 조사하였으며, Bacillus subtilis ATCC 6633, Staphyloccus aureus IFO 12732, Micrococcus luteus ATCC 9341 및 Kebsiella pueumouiae KCTC 1560의 균주들에 대해서는 강한 항균력을 보여주었다. 그러나 Mycrobacterium phlei IFO 3158, Salmonella typhimurium KCTC 1925, Escherichia coli BE 1186, Escherichia coli AB 0111 및 Pseudomonas aeruginosa IFO 13130의 균주들에 대해서는 유사한 항균력을 나타냈다. 한편 sulfadiazine 항균제가 진균류에 대하여 감수성을 보이지 않는 것처럼 중합체약에 있어서도 Candida albicans IFO 1594 균주는 항균력을 나타내지 않았다.

The synthetic procedures of polyacryloylsulfadiazine were searched by DCC and Acid Chloride methods. Polymeric drug was synthesized by Acid Chloride method In high yield but DCC method in low yield. The antimicrobial activities of polymeric drug was investigated in terms of minimum inhibitory concentrations by the common twofold dilution technique. Polymeric drug revealed an excellent antimicrobial activity against Bacillus subtilis ATCC 6633, Staphyloccus aureus IFO 12732, Micrococcus luteus ATCC 9341, Klebsiella pueumouiae KCTC 1560, and similar to Mycrobacterium phlei IFO 3158, Salmonella typhimurium KCTC 1925, Escherichia coli BE 1186, Escherichia coli AB 0111, Pseudomonas aeruginosa IFO 13130. Polymeric drug have no antimicrobial activity against Candida albicans IFO 1594.

[References]

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[1] Langer RS, Wise DL, "Medical Applications of Controlled Release," 2, 2-12, CRC Press, Florida (1984)

[2] Johnson P, Lioyd-Jones JG, "Drug Delivery Systems," 7-28, Ellis Horwood Ltd., England (1987)

[3] Buckles RG, J. Biomed. Mater. Res., 17, 109 (1983)

[4] Hodnett EM, "Polymers as Antitumor Agents," 8, 323-328, Polymer News (1983)

[5] Ascoli F, Casinit G, Ferappi M, Tubaro E, J. Med. Chem., 10, 97 (1967)

[6] Kim SI, Cha WS, Na JW, Kim YH, Ko OH, J. Chem. Soc., 36, 282 (1992)

[7] Yu EK, Kwun KH, Cha WS, Na JW, J. Chem. Soc., 37, 677 (1993)

[8] Blout ER, Karlson RH, J. Am. Chem. Soc., 78, 941 (1956)

[9] U.S. Patent, 2,407,966 (1946)

[10] Mark HF, Gaylord NG, Bikales NM, "Encyclopedia of Polymer Science and Technology," 197-226, Interscience Pub., New York (1972)

[11] Rodriguez F, "Principles of Polymer Systems," 163-167, Hemisphere Pub., New York (1982)

[12] Brandrup J, Immergut EH, "Polymer Handbook," IV-9, Wiley-Interscience Pub., New York (1975)

[13] Kim YS, Ko OH, Kang HR, Yakhak Hoeji, 34, 120 (1990)