Chirality-that is, left- or right-handedness-is an important concept in a broad range of scientific areas. In condensed matter, chirality is found not only in molecular or crystal forms, but also in magnetic structures. A magnetic skyrmion(1-8) is a topologically stable spin vortex structure, as observed in chiral-lattice helimagnets, and is one example of such a structure. The spin swirling direction (skyrmion helicity) should be closely related to the underlying lattice chirality via the relativistic spinorbit coupling. Here, we report on the correlation between skyrmion helicity and crystal chirality in alloys of helimagnets Mn1-xFexGe with varying compositions by Lorentz transmission electron microscopy and convergent-beam electron diffraction over a broad range of compositions (x = 0.31.0). The skyrmion lattice constant shows non-monotonous variation with composition x, with a divergent behaviour around x = 0.8, where the correlation between magnetic helicity and crystal chirality changes sign. This originates from continuous variation of the spin-orbit coupling strength and its sign reversal in the metallic alloys as a function of x. Controllable spinorbit coupling may offer a promising way to tune skyrmion size and helicity.