Novel blend microspheres of cellulose triacetate and bee wax for the controlled release of nateglinide

Praveen B. Kajjari; Lata S. Manjeshwar; Tejraj M. Aminabhavi

Journal of Industrial and Engineering Chemistry, Vol.20, No.2, 397-404, March, 2014

DOI10.1016/j.jiec.2013.04.034 Export Citation

Novel blend microspheres of cellulose triacetate and bee wax for the controlled release of nateglinide

Praveen B. Kajjari, Lata S. Manjeshwar^†, and Tejraj M. Aminabhavi¹

Department of Chemistry, Karnatak University, Dharwad 580 003, India
¹All India Council for Technical Education, SET’s College of Pharmacy, Dharwad 580 002, India

E-mail:

Blend microspheres of cellulose triacetate (CTA) and bee wax (BW) were prepared by oil-in-water (o/w) emulsion/solvent evaporation method for investigating the controlled release (CR) of nateglinide (NTG), an antidiabetic drug with a plasma half-life of 1.5 h. The novel carrier was analyzed for surface morphology, particle size, drug.polymer interactions, physical state of the encapsulated drug and micromeritic properties. In vitro release experiments were performed in simulated gastric (pH 1.2) and intestinal pH (7.4) media that was affected by blend composition and initial drug loading. In vitro release data were analyzed by empirical equations to understand the release profile of NTG

Keywords:Cellulose triacetate;Nateglinide;Bees wax;Controlled release;Solvent evaporation

[References]

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Shavi GV, Nayak U, Averineni RK, Arumugam K, Meka SR, Nayanabhirama U, Sureshwar P, Drug Dev. Ind. Pharm., 35, 252 (2009)
Abdul S, Chandewar AV, Jaiswal SB, J. Control. Release, 147, 2 (2010)
Soppimath KS, Aminabhavia TM, Kulkarni AR, Rudzinski WE, J. Control. Release, 70, 1 (2001)
Agnihotri SA, Mallikarjuna NN, Aminabhavi TM, J. Control. Release, 100, 5 (2004)
Buchanan CM, Gardner RM, Komarek RJ, J. Appl. Polym. Sci., 47, 1709 (1993)
Mayer JM, Elion GR, Buchanan CM, Sullivan BK, Pratt SD, Kaplan DL, J. Macromol. Sci.-Pure Appl. Chem., 32, 775 (1995)
Martı´n-Alfonso JE, Nunez N, Valencia C, Franco JM, Dı´az MJ, J. Ind. Eng. Chem., 17(5-6), 818 (2011)
Kee CM, Idris A, J. Ind. Eng. Chem., 18(6), 2115 (2012)
Soppimath KS, Kulkarni AR, Aminabhavi TM, J. Microencapsul., 18(3), 397 (2001)
Rokhade AP, Patil SA, Belhekar AA, Halligudi SB, Aminabhavi TM, J. Appl. Polym. Sci., 105(5), 2764 (2007)
Chaturvedi K, Kulkarni AR, Aminabhavi TM, Ind. Eng. Chem. Res., 50(18), 10414 (2011)
Sunitha S, Amareshwar P, Santhosh Kumar M, Asian Journal of Pharmaceutical and Clinical Research, 3, 4 (2010)
Tabata Y, Ikada Y, Biomaterials, 9, 1988 (356)
Fan XS, Liu ZT, Liu ZW, J. Hazard. Mater., 177(1-3), 452 (2010)
Tsai YL, Tien HT, Chen H, J. Microencapsul., 17, 413 (2000)
Kamble R, Maheshwari M, Paradkar A, Kadam S, AAPS PharmSciTech, 5, 75 (2004)
Huang HP, Mehta SC, Radebaugh GW, Fawzi MB, J. Pharm. Sci., 83, 795 (1994)
Gifani A, Taghizadeh M, Seifkordi AA, Ardjmand M, J. Microencapsul., 26(6), 485 (2009)
Kawashima Y, Ohno H, Takenaka H, J. Pharm. Sci., 70, 913 (1981)
Roblegg E, Ja¨ger E, Hodzic A, Koscher G, Mohr S, Zimmer A, Khinast J, Eur. J. Pharm. Biopharm., 79, 635 (2011)
Miyagawaa Y, Okabea T, Yamaguchia Y, Miyajimaa M, Sato H, Sunada H, Int. J. Pharm., 138, 215 (1996)
Ranjha NM, Khan H, Naseem S, J. Mater. Sci. -Mater. Med., 21, 1621 (2010)
Gowda DV, Ravi V, Shivakumar HG, Hatna S, J. Mater. Sci. -Mater. Med., 20, 1447 (2009)
Itagaki S, Otsuka Y, Kubo S, Okumura H, Saito Y, Kobayashi M, Hirano T, Iseki K, Biochem. Biophys. Acta, 1688, 190 (2005)
Bell PM, Cuthbertson J, Patterson S, O’Harte FPM, Diabetes Research and Clinical Practice, 91, e68 (2011)
Rane BR, Gujarathi NA, Patel JK, J. Pharm. Sci. Res., 3, 4306 (2012)
Basu SK, Rajendran A, Chem. Pharm. Bull., 56, 1077 (2008)
Mankala SK, Korla AC, Gade S, J. Pharm. Res., 4, 2011 (2732)
Prameela Rani A, Teja PS, Archana N, Sekaran CB, Int. J. Pharm. Res., 1, 1632 (2009)
Khemariya P, Jain A, Goswami R, Bhargava M, Goswami S, Int. J. Pharm. Appl. Sci., 1, 104 (2010)
Dash S, Murthy PN, Nath L, Chowdhury P, Acta Poloniae Pharmaceutica . Drug Research, 67, 217 (2010)
Pani NR, Nath LK, Acharya S, Bhuniya B, J. Therm. Anal. Calorim., 108, 219 (2012)
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[Referenced By]

[1] Rudolph MW, Klein S, Beckert TE, Petereit H, Dressman JB, Eur. J. Pharm. Biopharm., 51, 183 (2001)

[2] Shavi GV, Nayak U, Averineni RK, Arumugam K, Meka SR, Nayanabhirama U, Sureshwar P, Drug Dev. Ind. Pharm., 35, 252 (2009)

[3] Abdul S, Chandewar AV, Jaiswal SB, J. Control. Release, 147, 2 (2010)

[4] Soppimath KS, Aminabhavia TM, Kulkarni AR, Rudzinski WE, J. Control. Release, 70, 1 (2001)

[5] Agnihotri SA, Mallikarjuna NN, Aminabhavi TM, J. Control. Release, 100, 5 (2004)

[6] Buchanan CM, Gardner RM, Komarek RJ, J. Appl. Polym. Sci., 47, 1709 (1993)

[7] Mayer JM, Elion GR, Buchanan CM, Sullivan BK, Pratt SD, Kaplan DL, J. Macromol. Sci.-Pure Appl. Chem., 32, 775 (1995)

[8] Martı´n-Alfonso JE, Nunez N, Valencia C, Franco JM, Dı´az MJ, J. Ind. Eng. Chem., 17(5-6), 818 (2011)

[9] Kee CM, Idris A, J. Ind. Eng. Chem., 18(6), 2115 (2012)

[10] Soppimath KS, Kulkarni AR, Aminabhavi TM, J. Microencapsul., 18(3), 397 (2001)

[11] Rokhade AP, Patil SA, Belhekar AA, Halligudi SB, Aminabhavi TM, J. Appl. Polym. Sci., 105(5), 2764 (2007)

[12] Chaturvedi K, Kulkarni AR, Aminabhavi TM, Ind. Eng. Chem. Res., 50(18), 10414 (2011)

[13] Sunitha S, Amareshwar P, Santhosh Kumar M, Asian Journal of Pharmaceutical and Clinical Research, 3, 4 (2010)

[14] Tabata Y, Ikada Y, Biomaterials, 9, 1988 (356)

[15] Fan XS, Liu ZT, Liu ZW, J. Hazard. Mater., 177(1-3), 452 (2010)

[16] Tsai YL, Tien HT, Chen H, J. Microencapsul., 17, 413 (2000)

[17] Kamble R, Maheshwari M, Paradkar A, Kadam S, AAPS PharmSciTech, 5, 75 (2004)

[18] Huang HP, Mehta SC, Radebaugh GW, Fawzi MB, J. Pharm. Sci., 83, 795 (1994)

[19] Gifani A, Taghizadeh M, Seifkordi AA, Ardjmand M, J. Microencapsul., 26(6), 485 (2009)

[20] Kawashima Y, Ohno H, Takenaka H, J. Pharm. Sci., 70, 913 (1981)

[21] Roblegg E, Ja¨ger E, Hodzic A, Koscher G, Mohr S, Zimmer A, Khinast J, Eur. J. Pharm. Biopharm., 79, 635 (2011)

[22] Miyagawaa Y, Okabea T, Yamaguchia Y, Miyajimaa M, Sato H, Sunada H, Int. J. Pharm., 138, 215 (1996)

[23] Ranjha NM, Khan H, Naseem S, J. Mater. Sci. -Mater. Med., 21, 1621 (2010)

[24] Gowda DV, Ravi V, Shivakumar HG, Hatna S, J. Mater. Sci. -Mater. Med., 20, 1447 (2009)

[25] Itagaki S, Otsuka Y, Kubo S, Okumura H, Saito Y, Kobayashi M, Hirano T, Iseki K, Biochem. Biophys. Acta, 1688, 190 (2005)

[26] Bell PM, Cuthbertson J, Patterson S, O’Harte FPM, Diabetes Research and Clinical Practice, 91, e68 (2011)

[27] Rane BR, Gujarathi NA, Patel JK, J. Pharm. Sci. Res., 3, 4306 (2012)

[28] Basu SK, Rajendran A, Chem. Pharm. Bull., 56, 1077 (2008)

[29] Mankala SK, Korla AC, Gade S, J. Pharm. Res., 4, 2011 (2732)

[30] Prameela Rani A, Teja PS, Archana N, Sekaran CB, Int. J. Pharm. Res., 1, 1632 (2009)

[31] Khemariya P, Jain A, Goswami R, Bhargava M, Goswami S, Int. J. Pharm. Appl. Sci., 1, 104 (2010)

[32] Dash S, Murthy PN, Nath L, Chowdhury P, Acta Poloniae Pharmaceutica . Drug Research, 67, 217 (2010)

[33] Pani NR, Nath LK, Acharya S, Bhuniya B, J. Therm. Anal. Calorim., 108, 219 (2012)

[34] Korsmeyer RW, Lustig SR, Peppas NA, J. Polym. Sci. B: Polym. Phys., 24, 395 (1986)