Biocompatible Ag Nanoparticle-Embedded Poly(2-hydroxyethyl methacrylate) Derivative Films with Bacterial Adhesion-Resistant and Antibacterial Properties

Jooyeon Ahn; Eun-Ho Sohn; Suk Ho Bang; Junil Kang; Taeyoung Kim; Hyunkee Hong; Seong-Eun Kim; Byung-Soo Kim; Jeyong Yoon; Jong-Chan Lee

Macromolecular Research, Vol.22, No.3, 337-343, March, 2014

DOI10.1007/s13233-014-2050-9 Export Citation

Biocompatible Ag Nanoparticle-Embedded Poly(2-hydroxyethyl methacrylate) Derivative Films with Bacterial Adhesion-Resistant and Antibacterial Properties

Jooyeon Ahn, Eun-Ho Sohn¹, Suk Ho Bang, Junil Kang, Taeyoung Kim, Hyunkee Hong, Seong-Eun Kim, Byung-Soo Kim , Jeyong Yoon , and Jong-Chan Lee^†

Department of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul, 151-744, Korea
¹Interface Materials and Engineering Laboratory, Korea Research Institute of Chemical Technology, Daejon, 305-343, Korea

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Polymeric nanocomposite films of poly(2-hydroxyethyl methacrylate) (PHEMA) derivative, with ester side groups containing well-dispersed Ag nanoparticles, were prepared, using a very simple coating and reduction process. The nanocomposite films were stable in water because the matrix polymer, PHEMA derivative with ester side groups is relatively hydrophobic, while Ag nanoparticles are well dispersed in the polymer matrix, due to the oxygen-rich ester side groups of the polymer. By integrating the antibacterial effect of Ag nanoparticles onto the bacterial adhesion-resistant and biocompatible characters of the PHEMA derivative, polymer-Ag nanocomposite films having biocompatible, bacterial adhesion-resistant, and antibacterial properties could be produced. Moreover, a very small amount of Ag nanoparticles was found to greatly increase the stability of the polymer film in water, a leading to extending the applicable window in biological fields.

Keywords:poly(2-hydroxyethyl methacrylate) derivative;polymer/Ag nanocomposite;antibacterial;antifouling;biocompatibility.

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Sohn EH, Kim J, Kim BG, Kang JI, Chung JS, Ahn J, Yoon J, Lee JC, Colloids Surf. B, 77, 191 (2010)
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Mary G, Bajpai SK, Chand N, J. Appl. Polym. Sci., 113(2), 757 (2009)
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[Related Articles]

[1] Hall-Stoodley L, Costerton JW, Stoodley P, Nat. Rev. Microbiol., 2, 95 (2004)

[2] Banerjee I, Pangule RC, Kane RS, Adv. Mater., 23(6), 690 (2011)

[3] Park KD, Kim YS, Han DK, Kim YH, Lee EHB, Suh H, Choi KS, Biomaterials, 19, 851 (1998)

[4] Cheng G, Xite H, Zhang Z, Chen SF, Jiang SY, Angew. Chem. Int. Ed., 47, 8831 (2008)

[5] Sohn EH, Kim J, Kim BG, Kang JI, Chung JS, Ahn J, Yoon J, Lee JC, Colloids Surf. B, 77, 191 (2010)

[6] Lee SB, Koepsel RR, Morley SW, Matyjaszewski K, Sun YJ, Russell AJ, Biomacromolecules, 5(3), 877 (2004)

[7] Mary G, Bajpai SK, Chand N, J. Appl. Polym. Sci., 113(2), 757 (2009)

[8] Sohn EH, Ahn J, Bhang SH, Kang J, Yoon J, Kim BS, Lee JC, Macromol. Biosci., 12, 211 (2012)

[9] Sohn EH, Lee M, Song K, Macromol. Res., 21(2), 234 (2013)

[10] Lee HY, Park HK, Lee YM, Kim K, Park SB, Chem. Commun., 46, 2959 (2007)

[11] AshaRani PV, Mun GLK, Hande MP, Valiyaveettil S, ACS Nano, 3, 279 (2009)

[12] Youn MH, Lim YM, Gwon HJ, Park JS, An SJ, Nho YC, Macromol. Res., 17(10), 813 (2009)

[13] Sondi I, Salopek-Sondi B, J. Colloid Interface Sci., 275(1), 177 (2004)

[14] Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, Kim SH, Park YK, Park YH, Hwang CY, Kim YK, Lee YS, Jeong DH, Cho MH, Nanomedicine, 3, 95 (2007)

[15] Hatchett DW, White HS, J. Phys. Chem., 100(23), 9854 (1996)

[16] de Lima R, Seabra AB, Duran N, J. Appl. Toxicol., 32, 867 (2012)

[17] Yang X, Gondikas AP, Marinakos SM, Auffan M, Liu J, Kim GH, Meyer JN, Environ. Sci. Technol., 46, 1119 (2012)

[18] Ge X, Leng Y, Bao C, Xu SL, Wang R, Ren F, J. Biomed. Mater. Res., 95, 588 (2010)

[19] Friend of Industry Technology Information (FITI) Testing & Research Institute, Antibacterial of polymeric materials (FC-TM-20). (2001)

[20] Jeon HJ, Yi SC, Oh SG, Biomaterials, 24, 4921 (2003)

[21] Mihai R, Florescu IP, Coroiu V, Oancea A, Lungu M, J. Med. Life, 4, 250 (2011)

[22] Lizmarzan LM, Ladotourino I, Langmuir, 12(15), 3585 (1996)

[23] Zhang D, Qi L, Ma J, Cheng H, Chem. Mater., 13, 2753 (2001)

[24] Chen CW, Serizawa T, Akashi M, Langmuir, 15(23), 7998 (1999)

[25] Kang SY, Kim K, Langmuir, 14(1), 226 (1998)

[26] Chou CW, Hsu S, Chang H, Tseng SM, Lin HR, Polym. Degrad. Stab., 91, 1017 (2006)

[27] Mbhele ZH, Salemane MG, van Sittert CGCE, Nedeljkovic JM, Djokovic V, Luyt AS, Chem. Mater., 15, 5019 (2003)

[28] Xing ZC, Chae WP, Baek JY, Choi MJ, Jung Y, Kang IK, Biomacromolecules, 11(5), 1248 (2010)

[29] Agarwal A, Weis TL, Schurr MJ, Faith NG, Czuprynski CJ, McAnulty JF, Murphy CJ, Abbott NL, Biomaterials, 31, 680 (2010)