위산 환경에서 피막형 스텐트의 물성 변화

박성철; 박낙순; 김동곤; 나재운; 진윤태; 조혜진; 김은선; 금보라; 서연석; 이홍식; 전훈재; 엄순호; 김창덕; 류호상; Sung Chul Park; Nark-Soon Park; Dong-Gon Kim; Jae-Woon Nah; Yoon Tae Jeen; Hye Jin Cho; Eun Sun Kim; Bora Keum; Yeon Seok Seo; Hong Sik Lee; Hoon Jai Chun; Soon Ho Um; Chang Duck Kim; Ho Sang Ryu

Polymer(Korea), Vol.38, No.3, 351-357, May, 2014

Export Citation

위산 환경에서 피막형 스텐트의 물성 변화

Physical Properties of Covered Stent in Gastric Acid Environment: In Vitro Study

박성철, 박낙순¹, 김동곤², 나재운 ³, 진윤태^{1, †}, 조혜진¹, 김은선¹, 금보라¹, 서연석¹, 이홍식¹, 전훈재¹, 엄순호¹, 김창덕¹, 류호상¹

강원대학교 의학전문대학원 내과학교실
¹고려대학교 의과대학 내과학교실
²(재)유타-인하 DDS 및 신의료기술개발 공동연구소
³순천대학교 고분자공학과

Sung Chul Park, Nark-Soon Park¹, Dong-Gon Kim², Jae-Woon Nah³, Yoon Tae Jeen^{1, †}, Hye Jin Cho¹, Eun Sun Kim¹, Bora Keum¹, Yeon Seok Seo¹, Hong Sik Lee¹, Hoon Jai Chun¹, Soon Ho Um¹, Chang Duck Kim¹, and Ho Sang Ryu¹

Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 200-701, Korea
¹Department of Internal Medicine, Korea University College of Medicine, Seoul 136-705, Korea
²Utah-inha DDS & Advanced Therapeutics Research Center, Incheon 406-840, Korea
³Department of Polymer Science and Engineering, Sunchon National University, Jeonnam 540-742 Korea

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초록

위장관 종양 조직이 스텐트 내로 성장하는 것을 방지하는 피막형 스텐트가 개발되어 널리 사용되고 있으나 위산에 의한 막의 분해로 인해 스텐트 폐쇄나 파손이 있다. 이에 본 연구에서는 위산 환경하에서 막의 성분과 재질 농도에 따른 피막형 스텐트의 물성 변화와 안정성을 살펴보고자 하였다. 스텐트 막의 재질은 실리콘과 폴리우레탄을 사용하였고, 각각의 농도를 15%, 18%, 20%로 하여 제작된 스텐트를 pH 1.2 산성 용액에서 18주 동안 3주 간격으로 변화를 관찰하였다. 피막을 분석한 결과 동일 농도에서 비교하였을 때 실리콘이 폴리우레탄보다 두껍고 균일하게 코팅되었다. 인공 위액에 의한 폴리우레탄 피막의 분해가 실리콘 피막에 비해 심하였다. 반경 방향 팽창력의 크기는 실리콘 피막이 폴리우레탄 피막에 비해 상대적으로 컸다. 반경 방향 팽창력과 변형 회복력 모두 인공 위액에서의 침잠 기간이 경과함에 따라 점차 감소하였고, 폴리우레탄 피막 스텐트에서 감소율이 더 컸다. 결론적으로 실리콘 피막이 폴리우레탄에 비해 위산에 대해 안정성이 높음을 알 수 있었다.

In membrane covered stent, occlusion and fracture from membrane degradation by gastric acid sometimes occurred. Therefore, we investigated the physical properties of membrane covered stent according to its ingredient and concentration in gastric acid environment. Membrane covered stents consisted of silicone and polyurethane with 15%, 18%, 20% concentrations were used. After incubating stents in a condition of pH 1.2, we checked any changes at every 3 weeks for 18 weeks. The changes of membrane surface, radial expansion and recovery force of stent were investigated. Coating thickness increased proportionally to an increase in ingredient concentration. Surface was evenly coated with silicone compared to the case with polyurethane and its homogeneity was excellent in a high concentration. Degradation was much severe in the case of polyurethane. The radial force of silicone was higher than polyurethane, and the decrease of radial and recovery force was higher in the case of polyurethane. In conclusion, high concentration of silicone membrane was more stable than polyurethane in acid environment of in vitro study.

Keywords:covered stent;physical property;gastric acid;silicone;polyurethane.

[References]

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Zhou JH, Jiang YG, Wang RW, Lin YD, Gong TQ, Zhao YP, Ma Z, Tan QY, J. Thorac. Cardiovasc. Surg., 130, 449 (2005)
Jung GS, Song HY, Seo TS, Park SJ, Koo JY, Huh JD, Cho YD, J. Vasc. Interv. Radiol., 13, 275 (2002)
Park HJ, Cho YK, Kim WT, J. Korea Radiol. Soc., 59, 321 (2008)
Saxon RR, Barton RE, Katon RM, Lakin PC, Timmermans HA, Uchida BT, Keller FS, Rosch J, J. Vasc. Interv. Radiol., 6, 237 (1995)
Schaer J, Katon RM, Ivancev K, Uchida B, Rosch J, Binmoeller K, Gastrointest. Endosc., 38, 7 (1992)
Kim JH, Song HY, Shin JH, Jung HY, Kim SB, Park SI, J. Vasc. Interv. Radiol., 19, 220 (2008)
Lee KB, Chun HJ, Kim YB, Kim YS, Park JH, Moon T, Hong D, Hyun JH, Korean J. Gastrointest. Endosc., 23, 61 (2001)
Isayama H, Komatsu Y, Tsujino T, Yoshida H, Tada M, Shiratori Y, Kawabe T, Omata M, Gastrointest. Endosc., 55, 366 (2002)
Saito H, Sakurai Y, Takamura A, Horio K, Nihon Igaku Hoshasen Gakkai Zasshi, 54, 180 (1994)
Bang BW, Jeong S, Lee DH, Lee JI, Lee SC, Kang SG, Dig. Dis. Sci., 57, 1056 (2012)
Kim DH, Kang SG, Choi JR, Byun JN, Kim YC, Ahn YM, Korean J. Radiol., 2, 75 (2001)
Mashak A, Rahimi A, Iran Polym. J., 18, 279 (2009)
Colas A, Curtis J, “Silicone biomaterials: history and chemistry”, in Biomaterials science: an introduction to materials in medicine, Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, Editors, Elsevier, Amsterdam, p 80 (2004)
McHenry MM, Smeloff EA, Fong WY, Miller GE, Ryan PM, J. Thorac. Cardiovasc. Surg., 59, 413 (1970)
Yasumori K, Mahmoudi N, Wright KC, Wallace S, Gianturco C, J. Vasc. Interv. Radiol., 4, 773 (1993)
Duda SH, Wiskirchen J, Tepe G, Bitzer M, Kaulich TW, Stoeckel D, Claussen CD, J. Vasc. Interv. Radiol., 11, 645 (2000)
Dyet JF, Watts WG, Ettles DF, Nicholson AA, Cardiovasc. Intervent. Radiol., 23, 47 (2000)
Miura S, Yoshioka T, Furuichi K, Tanaka T, Kichikawa K, Ohishi H, Nihon Igaku Hoshasen Gakkai Zasshi, 63, 201 (2003)
Stoeckel D, Pelton A, Duerig T, Eur. Radiol., 14, 292 (2004)
Isayama H, Nakai Y, Toyokawa Y, Togawa O, Gon C, Ito Y, Yashima Y, Yagioka H, Kogure H, Sasaki T, Arizumi T, Matsubara S, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Kawabe T, Omata M, Gastrointest. Endosc., 70, 37 (2009)

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[2] Zhou JH, Jiang YG, Wang RW, Lin YD, Gong TQ, Zhao YP, Ma Z, Tan QY, J. Thorac. Cardiovasc. Surg., 130, 449 (2005)

[3] Jung GS, Song HY, Seo TS, Park SJ, Koo JY, Huh JD, Cho YD, J. Vasc. Interv. Radiol., 13, 275 (2002)

[4] Park HJ, Cho YK, Kim WT, J. Korea Radiol. Soc., 59, 321 (2008)

[5] Saxon RR, Barton RE, Katon RM, Lakin PC, Timmermans HA, Uchida BT, Keller FS, Rosch J, J. Vasc. Interv. Radiol., 6, 237 (1995)

[6] Schaer J, Katon RM, Ivancev K, Uchida B, Rosch J, Binmoeller K, Gastrointest. Endosc., 38, 7 (1992)

[7] Kim JH, Song HY, Shin JH, Jung HY, Kim SB, Park SI, J. Vasc. Interv. Radiol., 19, 220 (2008)

[8] Lee KB, Chun HJ, Kim YB, Kim YS, Park JH, Moon T, Hong D, Hyun JH, Korean J. Gastrointest. Endosc., 23, 61 (2001)

[9] Isayama H, Komatsu Y, Tsujino T, Yoshida H, Tada M, Shiratori Y, Kawabe T, Omata M, Gastrointest. Endosc., 55, 366 (2002)

[10] Saito H, Sakurai Y, Takamura A, Horio K, Nihon Igaku Hoshasen Gakkai Zasshi, 54, 180 (1994)

[11] Bang BW, Jeong S, Lee DH, Lee JI, Lee SC, Kang SG, Dig. Dis. Sci., 57, 1056 (2012)

[12] Kim DH, Kang SG, Choi JR, Byun JN, Kim YC, Ahn YM, Korean J. Radiol., 2, 75 (2001)

[13] Mashak A, Rahimi A, Iran Polym. J., 18, 279 (2009)

[14] Colas A, Curtis J, “Silicone biomaterials: history and chemistry”, in Biomaterials science: an introduction to materials in medicine, Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, Editors, Elsevier, Amsterdam, p 80 (2004)

[15] McHenry MM, Smeloff EA, Fong WY, Miller GE, Ryan PM, J. Thorac. Cardiovasc. Surg., 59, 413 (1970)

[16] Yasumori K, Mahmoudi N, Wright KC, Wallace S, Gianturco C, J. Vasc. Interv. Radiol., 4, 773 (1993)

[17] Duda SH, Wiskirchen J, Tepe G, Bitzer M, Kaulich TW, Stoeckel D, Claussen CD, J. Vasc. Interv. Radiol., 11, 645 (2000)

[18] Dyet JF, Watts WG, Ettles DF, Nicholson AA, Cardiovasc. Intervent. Radiol., 23, 47 (2000)

[19] Miura S, Yoshioka T, Furuichi K, Tanaka T, Kichikawa K, Ohishi H, Nihon Igaku Hoshasen Gakkai Zasshi, 63, 201 (2003)

[20] Stoeckel D, Pelton A, Duerig T, Eur. Radiol., 14, 292 (2004)

[21] Isayama H, Nakai Y, Toyokawa Y, Togawa O, Gon C, Ito Y, Yashima Y, Yagioka H, Kogure H, Sasaki T, Arizumi T, Matsubara S, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Kawabe T, Omata M, Gastrointest. Endosc., 70, 37 (2009)