Hemorheological abnormalities in human arterial hypertension

Rosalia Lo Presti; Eugenia Hopps; Gregorio Caimi

Korea-Australia Rheology Journal, Vol.26, No.2, 199-204, May, 2014

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Hemorheological abnormalities in human arterial hypertension

Rosalia Lo Presti^†, Eugenia Hopps, and Gregorio Caimi

University of Palermo, Palermo, Italy

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Blood rheology is impaired in hypertensive patients. The alteration involves blood and plasma viscosity, and the erythrocyte behaviour is often abnormal. The hemorheological pattern appears to be related to some pathophysiological mechanisms of hypertension and to organ damage, in particular left ventricular hypertrophy and myocardial ischemia. Abnormalities have been observed in erythrocyte membrane fluidity, explored by fluorescence spectroscopy and electron spin resonance. This may be relevant for red cell flow in microvessels and oxygen delivery to tissues. Although blood viscosity is not a direct target of antihypertensive therapy, the rheological properties of blood play a role in the pathophysiology of arterial hypertension and its vascular complications.

Keywords:essential hypertension;blood viscosity;erythrocyte deformability;erythrocyte membrane

[References]

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Bogar L, Clin. Hemorheol. Microcirc., 26, 81 (2002)
Bor-Kucukatay M, Wenby RB, Meiselman HJ, Baskurt OK, Am. J. Physiol.-Heart C., 284, 1577 (2003)
Brook RD, Julius S, Am. J. Hypertens., 13, 112 (2000)
Caimi G, Catania A, Frazzetta F, Capobianco D, Sarno A, Jpn. Heart J., 24, 723 (1983)
Caimi G, Contorno A, Serra A, Catania A, Presti RL, Sarno A, Cerasola G, Clin. Hemorheol. Microcirc., 13, 35 (1993)
Caimi G, Contorno A, Serra A, Presti RL, Grif G, D’Asaro S, Catania A, Sarno A, Cerasola G, Microcirc., Endothelium Lymphatics, 7, 245 (1991)
Caimi G, Presti RL, Canino B, Montana M, Ferrara L, Oddo G, Ventimiglia G, Cerasola G, Clin. Hemorheol. Microcirc., 19, 281 (1998)
Caimi G, Morici ML, Capobianco D, Cerasola G, Sarno A, Minerva Cardioangiol., 32, 941 (1984)
Caimi G, Clin. Hemorheol. Microcirc., 17, 199 (1997)
Chabanel A, Chien S, In: Hypertension: pathophysiology, diagnosis and management, Laragh JH, Brenner BM, eds., New York, Raven Press Ltd, 329-337 (1990)
Chien S, Biorheology, 23, 633 (1986)
Devereux RB, Drayer JI, Chien S, Pickering TG, Letcher RL, DeYoung JL, Sealey JE, Laragh JH, Am. J. Cardiol., 54, 592 (1984)
Dintenfass L, Lake R, Lancet, 1, 1026 (1976)
Di Perri T, Forconi S, Di Lollo F, Pozza G, In: Atti dell’84 Congresso della Societ Italiana di Medicina Interna, Roma, Ediz. Luigi Pozzi, 193-310 (1983)
Forconi S, Gori T, Clin. Hemorheol. Microcirc., 42, 16 (2009)
Forconi S, Pieragalli D, Guerrini M, Galigani C, Cappelli R, Drugs, 33, 19 (1987)
Fornal M, Korbut RA, Krlczyk J, Grodzicki T, Clin. Hemorheol. Microcirc., 43, 201 (2009)
Fu YF, Dong YZ, Li H, Lu ZM, Wang W, Chinese Med. J., 105, 803 (1992)
Hacioglu G, Yalcin O, Bor-Kucukatay M, Ozkaya G, Baskurt OK, Clin. Hemorheol. Microcirc., 26, 27 (2002)
Harris I, McLoughlin G, Q. J. Med., 23, 451 (1930)
Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ, Thabet SR, Vinh A, Weyand CM, Hypertension, 57, 132 (2011)
Hopps E, Lo Presti R, Caimi G, Clin. Hemorheol. Microcirc., 41, 209 (2009)
Giles TD, Sander GE, Nossaman BD, Kadowitz PJ, J. Clin. Hypertens., 14, 198 (2012)
Intaglietta M, Biorheology, 45, 77 (2008)
Kaczmarska M, Fornal M, Messerli FH, Korecki J, Grodzicki T, Burda K, Cell Biochem. Biophys., 67, 1089 (2013)
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Meiselman HJ, Baskurt OK, Clin. Hemorheol. Microcirc., 35, 37 (2006)
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Robins JB, Woodward M, Lowe G, McCaul P, Cheyne H, Walker JJ, J. Obstet. Gynaecol., 25, 746 (2005)
Ronquist G, Frithz G, Gunnarson K, Arvidson G, J. Intern. Med., 232, 247 (1992)
Salazar Vazquez BY, Cabrales P, Tsai AG, Intaglietta M, Clin. Hemorheol. Microcirc., 49, 29 (2011)
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Sica DA, Mannino R, J. Clin. Hypertens., 9, 723 (2007)
Tsuda K, Nishio I, Am. J. Hypertens., 16, 259 (2003)
Tsuda K, Heart Vessels, 23, 134 (2008)
Vlahakos DV, Marathias KP, Madias NE, Am. J. Kidney Dis., 56, 558 (2010)
Von Tempelhoff GF, Velten E, Yilmaz A, Hommel G, Heilmann L, Koscielny J, Clin. Hemorheol. Microcirc., 42, 127 (2009)
Zannad F, Voisin P, Brunotte F, Bruntz JF, Stoltz JF, Gilgenkrantz JM, J. Hypertens., 6, 293 (1988)
Zicha J, Kunes J, Devynck MA, Am. J. Hypertens., 12, 315 (1999)

[1] Altenhofer S, Kleikers PWM, Radermacher KA, Scheurer P, Rob Hermans JJ, Schiffers P, Ho H, Wingler K, Schmidt HHHW, Cell. Mol. Life Sci., 69, 2327 (2012)

[2] Bogar L, Clin. Hemorheol. Microcirc., 26, 81 (2002)

[3] Bor-Kucukatay M, Wenby RB, Meiselman HJ, Baskurt OK, Am. J. Physiol.-Heart C., 284, 1577 (2003)

[4] Brook RD, Julius S, Am. J. Hypertens., 13, 112 (2000)

[5] Caimi G, Catania A, Frazzetta F, Capobianco D, Sarno A, Jpn. Heart J., 24, 723 (1983)

[6] Caimi G, Contorno A, Serra A, Catania A, Presti RL, Sarno A, Cerasola G, Clin. Hemorheol. Microcirc., 13, 35 (1993)

[7] Caimi G, Contorno A, Serra A, Presti RL, Grif G, D’Asaro S, Catania A, Sarno A, Cerasola G, Microcirc., Endothelium Lymphatics, 7, 245 (1991)

[8] Caimi G, Presti RL, Canino B, Montana M, Ferrara L, Oddo G, Ventimiglia G, Cerasola G, Clin. Hemorheol. Microcirc., 19, 281 (1998)

[9] Caimi G, Morici ML, Capobianco D, Cerasola G, Sarno A, Minerva Cardioangiol., 32, 941 (1984)

[10] Caimi G, Clin. Hemorheol. Microcirc., 17, 199 (1997)

[11] Chabanel A, Chien S, In: Hypertension: pathophysiology, diagnosis and management, Laragh JH, Brenner BM, eds., New York, Raven Press Ltd, 329-337 (1990)

[12] Chien S, Biorheology, 23, 633 (1986)

[13] Devereux RB, Drayer JI, Chien S, Pickering TG, Letcher RL, DeYoung JL, Sealey JE, Laragh JH, Am. J. Cardiol., 54, 592 (1984)

[14] Dintenfass L, Lake R, Lancet, 1, 1026 (1976)

[15] Di Perri T, Forconi S, Di Lollo F, Pozza G, In: Atti dell’84 Congresso della Societ Italiana di Medicina Interna, Roma, Ediz. Luigi Pozzi, 193-310 (1983)

[16] Forconi S, Gori T, Clin. Hemorheol. Microcirc., 42, 16 (2009)

[17] Forconi S, Pieragalli D, Guerrini M, Galigani C, Cappelli R, Drugs, 33, 19 (1987)

[18] Fornal M, Korbut RA, Krlczyk J, Grodzicki T, Clin. Hemorheol. Microcirc., 43, 201 (2009)

[19] Fu YF, Dong YZ, Li H, Lu ZM, Wang W, Chinese Med. J., 105, 803 (1992)

[20] Hacioglu G, Yalcin O, Bor-Kucukatay M, Ozkaya G, Baskurt OK, Clin. Hemorheol. Microcirc., 26, 27 (2002)

[21] Harris I, McLoughlin G, Q. J. Med., 23, 451 (1930)

[22] Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ, Thabet SR, Vinh A, Weyand CM, Hypertension, 57, 132 (2011)

[23] Hopps E, Lo Presti R, Caimi G, Clin. Hemorheol. Microcirc., 41, 209 (2009)

[24] Giles TD, Sander GE, Nossaman BD, Kadowitz PJ, J. Clin. Hypertens., 14, 198 (2012)

[25] Intaglietta M, Biorheology, 45, 77 (2008)

[26] Kaczmarska M, Fornal M, Messerli FH, Korecki J, Grodzicki T, Burda K, Cell Biochem. Biophys., 67, 1089 (2013)

[27] Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I, Gharini P, Kabanova S, Ozuyaman B, Schnurch HG, Godecke A, Weber AA, Robenek M, Robenek H, Bloch W, Rosen P, Kelm M, Blood, 107, 2943 (2006)

[28] Leschke M, Vogt M, Motz W, Strauer BE, Am. J. Cardiol., 65, 56 (1990)

[29] Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP, New Engl. J. Med., 322, 1561 (1990)

[30] Meiselman HJ, Baskurt OK, Clin. Hemorheol. Microcirc., 35, 37 (2006)

[31] Meiselman HJ, Clin. Hemorheol. Microcirc., 21, 195 (1999)

[32] Muriana FJ, Garcia-Donas MA, Villar J, Ruiz-Gutierrez V, J. Hypertens., 12, 1383 (1994)

[33] Muriana FJ, Montilla C, Villar J, Ruiz-Gutierrez V, J. Hypertens., 13, 619 (1995)

[34] Pytel E, Duchnowicz P, Jackowska P, Wojdan K, Koter-Michalak M, Broncel M, Med. Sci. Monitor, 18, 331 (2012)

[35] Robins JB, Woodward M, Lowe G, McCaul P, Cheyne H, Walker JJ, J. Obstet. Gynaecol., 25, 746 (2005)

[36] Ronquist G, Frithz G, Gunnarson K, Arvidson G, J. Intern. Med., 232, 247 (1992)

[37] Salazar Vazquez BY, Cabrales P, Tsai AG, Intaglietta M, Clin. Hemorheol. Microcirc., 49, 29 (2011)

[38] Schiffrin EL, Can. J. Cardiol., 29, 543 (2013)

[39] Sica DA, Mannino R, J. Clin. Hypertens., 9, 723 (2007)

[40] Tsuda K, Nishio I, Am. J. Hypertens., 16, 259 (2003)

[41] Tsuda K, Heart Vessels, 23, 134 (2008)

[42] Vlahakos DV, Marathias KP, Madias NE, Am. J. Kidney Dis., 56, 558 (2010)

[43] Von Tempelhoff GF, Velten E, Yilmaz A, Hommel G, Heilmann L, Koscielny J, Clin. Hemorheol. Microcirc., 42, 127 (2009)

[44] Zannad F, Voisin P, Brunotte F, Bruntz JF, Stoltz JF, Gilgenkrantz JM, J. Hypertens., 6, 293 (1988)

[45] Zicha J, Kunes J, Devynck MA, Am. J. Hypertens., 12, 315 (1999)