Pancreas-Like Extracellular Matrix Scaffold for Successful Pancreatic Islet Transplantation

Min Jun Kim; Dong Yun Lee

Macromolecular Research, Vol.22, No.6, 575-582, June, 2014

DOI10.1007/s13233-014-2097-7 Export Citation

Pancreas-Like Extracellular Matrix Scaffold for Successful Pancreatic Islet Transplantation

Min Jun Kim¹, and Dong Yun Lee^{1, 2, †}

¹Department of Bioengineering, College of Engineering, Hanyang University, Seoul, 133-791, Korea
²BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul, 133-791, Korea

E-mail:

In clinical islet transplantation, intrahepatically transplanted islets are generally rejected by the host’s immune response. However, they are also rapidly destroyed by other mechanisms that are unrelated to immune response. For example, isolated islets can lose the natural pancreatic microenvironment during the islet isolation process, leading to islet cell apoptosis and early graft failure. In a normal pancreas, islets are surrounded by extracellular matrix (ECM) components such as collagen, laminin, fibronectin, and so on. The interactions between islets and these ECM molecules may be very important for islet physiology in the native pancreas. By modulating intracellular signaling pathways, ECM components may play an important role in islet differentiation, proliferation, survival, and insulin secretion. However, the role of ECM molecules in regulation of pancreatic islets is still completely unknown. This article reviews current knowledge of islet-ECM interactions, evaluating the possible use of ECM molecules in improving islet transplantation outcomes. It also discusses several experimental trials of methods for enhancing the viability and functionality of islets.

Keywords:islet transplantation;extracellular matrix;pancreas-like scaffold;diabetes.

[References]

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Bosman FT, Stamenkovic I, J. Pathol., 200, 423 (2003)
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Kaido T, Yebra M, Cirulli V, Rhodes C, Diaferia G, Montgomery AM, Diabetes, 55, 2723 (2006)
Bosco D, Meda P, Halban PA, Rouiller DG, Diabetes, 49, 233 (2000)
Oberg-Welsh C, Pancreas, 22, 157 (2001)
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Henquin JC, Diabetes, 49, 1751 (2000)
Langhofer M, Hopkinson SB, Jones JCR, J. Cell Sci., 105, 753 (1993)
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Brelje TC, Parsons JA, Sorenson RL, Diabetes, 43, 263 (1994)
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[2] Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JRT, Shapir AMJ, Diabetes, 54, 2060 (2005)

[3] Rosenberg L, Wang RN, Paraskevas S, Maysinger D, Surgery, 126, 393 (1999)

[4] Hammar E, Parnaud G, Bosco D, Perriraz N, Maedler K, Donath M, Rouiller DG, Halban PA, Diabetes, 53, 2034 (2004)

[5] Hammar EB, Irminger JC, Rickenbach K, Parnaud G, Ribaux P, Bosco D, Rouiller DG, Halban PA, J. Biol. Chem., 280, 30630 (2005)

[6] Hayek A, Beattie GM, Cirulli V, Lopez AD, Ricordi C, Rubin JS, Diabetes, 44, 1458 (1995)

[7] Lucasclerc C, Massart C, Campion JP, Launois B, Nicol M, Mol. Cell. Endocrinol., 94, 9 (1993)

[8] Thomas FT, Contreras JL, Bilbao G, Ricordi C, Curiel D, Thomas JM, Surgery, 126, 299 (1999)

[9] Bosman FT, Stamenkovic I, J. Pathol., 200, 423 (2003)

[10] Myllyharju J, Kivirikko KI, Ann. Med., 33, 7 (2001)

[11] Szpak P, J. Archaeol. Sci., 38, 3358 (2011)

[12] van Deijnen JH, Hulstaert CE, Wolters GH, van Schilfgaarde R, Cell Tissue Res., 267, 139 (1992)

[13] Pinkse GG, Bouwman WP, Jiawan-Lalai R, Terpstra OT, Bruijn JA, de Heer E, Diabetes, 55, 312 (2006)

[14] Hynes RO, Cell, 69, 11 (1992)

[15] McCall-Culbreath KD, Zutter MM, Curr. Drug Targets, 9, 139 (2008)

[16] Chin GS, Lee S, Hsu M, Liu W, Kim WJH, Levinson H, Longaker MT, Plast. Reconstr. Surg., 107, 769 (2001)

[17] Miosge N, Holzhausen S, Zelent C, Sprysch P, Herken R, Histochem. J., 33, 523 (2001)

[18] Tunggal P, Smyth N, Paulsson M, Ott MC, Microsc. Res. Tech., 51, 214 (2000)

[19] Mercurio AM, Trends Cell Biol., 5, 419 (1995)

[20] Aumailley M, Smyth N, J. Anat., 193, 1 (1998)

[21] Giancotti FG, Ruoslahti E, Science, 285, 1028 (1999)

[22] Carter WG, Kaur P, Gil SG, Gahr PJ, Wayner EA, J. Cell Biol., 111, 3141 (1990)

[23] Hinek A, Biol. Chem., 377, 471 (1996)

[24] Jiang FX, Naselli G, Harrison LC, J. Histochem. Cytochem., 50, 1625 (2002)

[25] Crisera CA, Kadison AS, Breslow GD, Maldonado TS, Longaker MT, Gittes GK, Diabetes, 49, 936 (2000)

[26] Singh P, Carraher C, Schwarzbauer JE, Annu. Rev. Cell Dev. Biol., 26, 397 (2010)

[27] Johansson S, Svineng G, Wennerberg K, Armulik A, Lohikangas L, Front. Biosci., 2, 126 (1997)

[28] Miyamoto S, Katz BZ, Lafrenie RM, Yamada KM, Ann. N. Y. Acad. Sci., 857, 119 (1998)

[29] Pankov R, Yamada KM, J. Cell Sci., 115, 3861 (2002)

[30] Hall H, Bozic D, Michel K, Hubbell JA, Mol. Cell. Neurosci., 24, 1062 (2003)

[31] Bernfield M, Sanderson RD, Philos. Trans. R. Soc. Lond., B, Biol. Sci., 327, 171 (1990)

[32] Kaido T, Perez B, Yebra M, Hill J, Cirulli V, Hayek A, Montgomery AM, J. Biol. Chem., 279, 17731 (2004)

[33] Beattie GM, Cirulli V, Lopez AD, Hayek A, J. Clin. Endocrinol. Metab., 82, 1852 (1997)

[34] Jiang FX, Cram DS, DeAizpurua HJ, Harrison LC, Diabetes, 48, 722 (1999)

[35] Wang RN, Rosenberg L, J. Endocrinol., 163, 181 (1999)

[36] Green DR, Reed JC, Science, 281(5381), 1309 (1998)

[37] Carragher NO, Fincham VJ, Riley D, Frame MC, J. Biol. Chem., 276, 4270 (2001)

[38] Wolf BB, Green DR, J. Biol. Chem., 274, 20049 (1999)

[39] Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT, Mol. Cell. Biol., 14, 1680 (1994)

[40] Parsons SJ, Parsons JT, Oncogene, 23, 7906 (2004)

[41] Duriez PJ, Wong F, Dorovini-Zis K, Shahidi R, Karsan A, J. Biol. Chem., 275, 18099 (2000)

[42] Gauthier R, Harnois C, Drolet JF, Reed JC, Vezina A, Vachon PH, Am. J. Physiol. Cell. Physiol., 280, 1540 (2001)

[43] Breitschopf K, Haendeler J, Malchow P, Zeiher AM, Dimmeler S, Mol. Cell. Biol., 20, 1886 (2000)

[44] Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC, J. Biol. Chem., 273, 16305 (1998)

[45] Kaido T, Yebra M, Cirulli V, Rhodes C, Diaferia G, Montgomery AM, Diabetes, 55, 2723 (2006)

[46] Bosco D, Meda P, Halban PA, Rouiller DG, Diabetes, 49, 233 (2000)

[47] Oberg-Welsh C, Pancreas, 22, 157 (2001)

[48] Beattie GM, Montgomery AMP, Lopez AD, Hao E, Perez B, Just ML, Lakey JRT, Hart ME, Hayek A, Diabetes, 51, 3435 (2002)

[49] Daoud J, Petropavlovskaia M, Rosenberg L, Tabrizian M, Biomaterials, 31, 1676 (2010)

[50] Ashcroft FM, Gribble FM, Diabetologia, 42, 903 (1999)

[51] Henquin JC, Diabetes, 49, 1751 (2000)

[52] Langhofer M, Hopkinson SB, Jones JCR, J. Cell Sci., 105, 753 (1993)

[53] Nielsen JH, Galsgaard ED, Moldrup A, Friedrichsen BN, Billestrup N, Hansen JA, Lee YC, Carlsson C, Diabetes, 50, 25 (2001)

[54] Brelje TC, Scharp DW, Lacy PE, Ogren L, Talamantes F, Robertson M, Friesen HG, Sorenson RL, Endocrinology, 132, 879 (1993)

[55] Brelje TC, Parsons JA, Sorenson RL, Diabetes, 43, 263 (1994)

[56] Labriola L, Montor WR, Krogh K, Lojudice FH, Genzini T, Goldberg AC, Eliaschewitz FG, Sogayar MC, Mol. Cell. Endocrinol., 263, 120 (2007)

[57] CarterSu C, Schwartz J, Smit LS, Annu. Rev. Physiol., 58, 187 (1996)

[58] A Abbott, Nature, 424, 870 (2003)

[59] Otsuka H, Nagasaki Y, Kataoka K, Biomacromolecules, 1(1), 39 (2000)

[60] Herman S, Hooftman G, Schacht E, J. Bioact. Compat. Polym., 10, 145 (1995)

[61] Weber LM, Hayda KN, Anseth KS, Tissue Eng. Part A, 14, 1959 (2008)

[62] Blomeier H, Zhang XM, Rives C, Brissova M, Hughes E, Baker M, Powers AC, Kaufman DB, Shea LD, Lowe WL, Transplantation, 82, 452 (2006)

[63] Salvay DM, Rives CB, Zhang XM, Chen F, Kaufman DB, Lowe WL, Shea LD, Transplantation, 85, 1456 (2008)

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[66] Yucel T, Cebe P, Kaplan DL, Biophys. J., 97, 2044 (2009)

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[69] Schinkothe T, Bloch W, Schmidt A, Stem Cells Dev., 17, 199 (2008)

[70] Yucel T, Cebe P, Kaplan DL, Biophys. J., 97, 2044 (2009)

[71] Liu H, Chen B, Lilly B, Angiogenesis, 11, 223 (2008)

[72] Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JC, Trent JM, Staudt LM, Hudson J, Boguski MS, Lashkari D, Shalon D, Botstein D, Brown PO, Science, 283, 83 (1999)

[73] Jalili RB, Moeen Rezakhanlou A, Hosseini-Tabatabaei A, Ao Z, Warnock GL, Ghahary A, J. Cell. Physiol., 226, 1813 (2011)

[74] Li M, Moeen Rezakhanlou A, Chavez-Munoz C, Lai A, Ghahary A, Mol. Cell. Biochem., 332, 1 (2009)

[75] Chen F, Yoo JJ, Atala A, Urology, 54, 407 (1999)

[76] Harper C, Br. J. Hosp. Med., 62, 90 (2001)

[77] Badylak SF, Transpl. Immunol., 12, 367 (2004)

[78] Exposito JY, Dalessio M, Solursh M, Ramirez F, J. Biol. Chem., 267, 15559 (1992)

[79] Constantinou CD, Jimenez SA, Matrix, 11, 1 (1991)

[80] De Carlo E, Baiguera S, Conconi MT, Vigolo S, Grandi C, Lora S, Martini C, Maffei P, Tamagno G, Vettor R, Sicolo N, Parnigotto PP, Int. J. Mol. Med., 25, 195 (2010)

[81] DeMerlis CC, Schoneker DR, Food Chem. Toxicol., 41, 319 (2003)