Mathematical model and experimental validation of the synergistic effect of selective enantioseparation of (S)-amlodipine from pharmaceutical wastewater using a HFSLM

Niti Sunsandee; Ura Pancharoen; Prakorn Ramakul; Milan Hronec; Natchanun Leepipatpiboon

Journal of Industrial and Engineering Chemistry, Vol.20, No.4, 1612-1622, July, 2014

DOI10.1016/j.jiec.2013.08.008 Export Citation

Mathematical model and experimental validation of the synergistic effect of selective enantioseparation of (S)-amlodipine from pharmaceutical wastewater using a HFSLM

Niti Sunsandee, Ura Pancharoen^†, Prakorn Ramakul¹, Milan Hronec², and Natchanun Leepipatpiboon^{3, †}

Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand
¹Department of Chemical Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom 73000, Thailand
²Department of Organic Technology, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic, Slovakia (Slovak Republic)
³Chromatography and Separation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand

E-mail:,

A case study on the synergistic enantioseparation of (S)-amlodipine from pharmaceutical wastewater by using hollow fiber supported liquid membrane (HFSLM) was examined. A chiral reaction flux mathematical model was applied. Optimum conditions achieved the highest percentages of extraction and stripping viz. 84% and 80%, respectively. Relevant parameters affecting the enantioseparation efficiency of (S)-amlodipine were determined. Standard deviation percentages were 2.31% for extraction and 1.26% for stripping. It was found that the mathematical model proved to be in good agreement with the experimental data.

Keywords:Mathematical model;Synergistic effect;(S)-Amlodipine;Pharmaceutical wastewater;HFSLM

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[2] Oktem YA, Ince O, Sallis P, Donnelly T, Ince BK, Bioresour. Technol., 99, 1089 (2007)

[3] Nakada N, Kiri K, Shinohara H, Harada A, Kuroda K, Takizawa S, Takada H, Environ. Sci. Technol., 42, 6347 (2008)

[4] Alistair BA, Eur. Mol. Biol. Org., 5, 1110 (2013)

[5] Rodriguez-Donis I, Gerbaud V, Arias-Barreto A, Joulia X, Comput. Aided Chem. Eng., 27, 1119 (2009)

[6] Samuel D, Raj S, Anjaneyulu Y, Process Biochem., 40, 165 (2005)

[7] Breuer M, Ditrich K, Habicher T, Hauer B, Kesseler M, Sturmer R, Zelinski T, Angew. Chem.-Int. Edit., 43, 788 (2004)

[8] Heng S, Yeung KL, Djafer M, Schrotter JC, J. Membr. Sci., 289(1-2), 67 (2007)

[9] Ramakul P, Mooncluen U, Yanachawakul Y, Leepipatpiboon N, J. Ind. Eng. Chem., 18(5), 1606 (2012)

[10] Rathore NS, Sonawane JV, Kumar A, Venugopalan AK, Singh RK, Bajpai DD, Shukla JP, J. Membr. Sci., 189, 119 (2010)

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[15] Wang Z, Cai CQ, Lin YT, Bian YR, Guo HQ, Chen XM, Sep. Purif. Technol., 79(1), 63 (2011)

[16] Panja S, Mohapatra PK, Tripathi SC, Gandhi PM, Janardan P, J. Hazard. Mater., 237-238, 339 (2012)

[17] Agarwal S, Reis MTA, Ismael MRC, Correia MJN, Carvalho JMR, Sep. Purif. Technol., 102, 103 (2013)

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[19] Tan B, Luo GS, Wang JD, Tetrahedron: Asymmetry, 17, 883 (2006)

[20] Tang KW, Chen YY, Liu JJ, Sep. Purif. Technol., 62(3), 681 (2008)

[21] Tan B, Luo GS, Wang JD, Sep. Purif. Technol., 53(3), 330 (2007)

[22] Zandkarimi M, Shafaati A, Foroutan SM, Iran. J. Pharm. Res., 7, 275 (2008)

[23] Zandkarimi M, Shafaati A, Foroutan SM, Lucy CA, DARU, 17(4), 269 (2009)

[24] O’Brien T, Crocker L, Thompson R, Thompson K, Toma PH, Conlon DA, Feibush B, Moeder C, Bicker G, Grinberg N, Anal. Chem., 69, 1999 (1997)

[25] Pancharoen U, Wongsawa T, Lothongkum AW, Sep. Sci. Technol., 46(14), 2183 (2011)

[26] Chaturabul S, Wongkaew K, Pancharoen U, Sep. Sci. Technol., 48(1), 93 (2013)

[27] Kittisupakorn P, Weerachaipichaskul W, Thitiyasook P, J. Ind. Eng. Chem., 13(6), 903 (2007)

[28] Chung YS, Ha MC, Resolution of the enantiomers of amlodipine, US Patent Application 2003/6646131 B2 (November 11, 2003).

[29] Fogler HS, Elements of Chemical Reaction Engineering, 4th ed., Prentice-Hall, New Jersey, 2005p. 253.