Investigation of micellar and phase separation phenomenon of phenothiazine drug promazine hydrochloride with anionic hydrotropes

Malik Abdul Rub; Abdullah M. Asiri; Naved Azum; Kabir-ud-Din

Journal of Industrial and Engineering Chemistry, Vol.20, No.4, 2023-2034, July, 2014

DOI10.1016/j.jiec.2013.09.027 Export Citation

Investigation of micellar and phase separation phenomenon of phenothiazine drug promazine hydrochloride with anionic hydrotropes

Malik Abdul Rub^{1, 2, †}, Abdullah M. Asiri^{1, 2}, Naved Azum^{1, 2}, and Kabir-ud-Din³

¹Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia
²Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
³Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India

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The purpose of the present study was to determine the influence of various anionic hydrotropes on the self-aggregation and phase behavior of amphiphilic drug promazine hydrochloride (PMZ) and to search for means which reduce/increase the values of critical micelle concentration (cmc) and boost/suppress the cloud point (CP), respectively, used in pharmaceutical formulations. By using regular solution theory (RST) and Rosen’s model various micellar and surface properties such as micellar composition, surface excess concentration (Γmax), interaction parameters (βm, βσ) etc. have been determined. The solution micellar behaviors were also investigated using Motomura and Rodenas models for defense and comparison of results. Thermodynamic parameters were also evaluated and discussed.

Keywords:Phenothiazine drug;Anionic hydrotropes;Interaction parameter;Aggregation;Phase separation

[References]

Balasubramanian D, Srinivas V, Gaikar VG, Sharma MM, J. Phys. Chem., 93, 3865 (1989)
Neuberg C, Biochem. Z., 76, 107 (1916)
Balasubramanian D, Friberg SE, in: Matijevic E (Ed.), Surface and Colloid Science, Plenum Press, New York, 1993.
Srivastava RC, Nagappa AN, Surface Activity in Drug Action, vol. 21, Amsterdam, The Netherlands, 2005.
Sarmiento F, Lopez-Fontan JL, Prieto V, Attwood D, Mosquera V, Colloid Polym. Sci., 27, 1144 (1997)
Taboada P, Attwood D, Ruso JM, Garcia M, Mosquera V, Phys. Chem. Chem. Phys., 2, 5175 (2000)
Attwood D, Adv. Colloid Interface Sci., 55, 271 (1995)
Clint JH, J. Chem. Soc.-Faraday Trans., 251, 1327 (1975)
Rubingh DN, Mittal KL, Solution Chemistry of Surfactants, Plenum, New York, 1979.
Motomura K, Yamanaka M, Aratono M, Colloid Polym. Sci., 262, 948 (1984)
Rodenas E, Valiente M, Villafruela MD, J. Phys. Chem. B, 103(21), 4549 (1999)
Zhou Q, Rosen MJ, Langmuir, 19(11), 4555 (2003)
Kabir-ud-Din, Rub MA, Naqvi AZ, J. Phys. Chem. B, 114(19), 6354 (2010)
Kabir-ud-Din, Rub MA, Naqvi AZ, J. Colloid Interface Sci., 354(2), 700 (2011)
Alam MS, Naqvi AZ, Kabir-ud-Din, Colloids Surf. B: Biointerfaces, 57, 204 (2007)
Kabir-ud-Din, Rub MA, Naqvi AZ, J. Chem. Eng. Data, 56(7), 3115 (2011)
Kabir-ud-Din, Al-Ahmadi MDA, Naqvi AZ, Akram M, J. Dispersion Sci. Technol., 30, 439 (2009)
Rub MA, Asiri AM, Azum N, Khan A, Khan AAP, Khan SB, Rahman MM, Kabir-ud-Din, J. Ind. Eng. Chem., http://dx.doi.org/10.1016/j.jiec.2013.02.019 (2013)
Britton HTS, 3rd ed., Hydrogen Ions: Their Determination and Importance in Pure and Industrial Chemistry, vol. 2, Chapman, London, 1942.
Attwood D, Florence AT, Surfactant Systems. Their Chemistry, Pharmacy and Biology, Chapman and Hall, New York, 1983.
Khan IA, Khanam AJ, Khan ZA, Kabir-ud-Din, J. Chem. Eng. Data, 55(11), 4775 (2010)
Schick MJ (Ed.), Nonionic Surfactants: Physical Chemistry, Dekker, New York, 1987.
Mosquera V, del Rio JM, Attwood D, Garcia M, Jones MN, Prieto G, Suarez MJ, Sarmiento F, J. Colloid Interface Sci., 206(1), 66 (1998)
Ruiz CC, Diaz-Lopez L, Aguiar J, J. Colloid Interface Sci., 305(2), 293 (2007)
Das C, Das B, J. Chem. Eng. Data, 54(2), 559 (2009)
Lange H, Beck KH, Kolloid Z. Z. Polym., 251, 424 (1973)
Rosen MJ, Surfactants and Interfacial Phenomenon, 3rd ed., Wiley-Interscience, New York, 2004.
Asakawa T, Kitano H, Ohta A, Miyagishi S, J. Colloid Interface Sci., 242(2), 284 (2001)
Iijima H, Kato T, Soderman O, Langmuir, 16(2), 318 (2000)
Rosen MJ, Aronson S, Colloids Surf., 3, 201 (1981)
Sugihara G, Miyazono AM, Nagadome S, Oida T, Hayashi Y, Ko JS, J. Oleo Sci., 52, 449 (2003)
Hoffmann H, Possnecker G, Langmuir, 10(2), 381 (1994)
Maeda H, J. Phys. Chem. B, 109(33), 15933 (2005)
Katzung BG, Basic and Clinical Pharmacology, 9th ed., McGraw Hill, New York, 2004
Laughlin RG, Adv. Liq. Crystals, 3, 41 (1978)
Rao URK, Manohar C, Valaulikar BS, Iyer RM, J. Phys. Chem., 91, 3286 (1987)

[Referenced By]

[1] Balasubramanian D, Srinivas V, Gaikar VG, Sharma MM, J. Phys. Chem., 93, 3865 (1989)

[2] Neuberg C, Biochem. Z., 76, 107 (1916)

[3] Balasubramanian D, Friberg SE, in: Matijevic E (Ed.), Surface and Colloid Science, Plenum Press, New York, 1993.

[4] Srivastava RC, Nagappa AN, Surface Activity in Drug Action, vol. 21, Amsterdam, The Netherlands, 2005.

[5] Sarmiento F, Lopez-Fontan JL, Prieto V, Attwood D, Mosquera V, Colloid Polym. Sci., 27, 1144 (1997)

[6] Taboada P, Attwood D, Ruso JM, Garcia M, Mosquera V, Phys. Chem. Chem. Phys., 2, 5175 (2000)

[7] Attwood D, Adv. Colloid Interface Sci., 55, 271 (1995)

[8] Clint JH, J. Chem. Soc.-Faraday Trans., 251, 1327 (1975)

[9] Rubingh DN, Mittal KL, Solution Chemistry of Surfactants, Plenum, New York, 1979.

[10] Motomura K, Yamanaka M, Aratono M, Colloid Polym. Sci., 262, 948 (1984)

[11] Rodenas E, Valiente M, Villafruela MD, J. Phys. Chem. B, 103(21), 4549 (1999)

[12] Zhou Q, Rosen MJ, Langmuir, 19(11), 4555 (2003)

[13] Kabir-ud-Din, Rub MA, Naqvi AZ, J. Phys. Chem. B, 114(19), 6354 (2010)

[14] Kabir-ud-Din, Rub MA, Naqvi AZ, J. Colloid Interface Sci., 354(2), 700 (2011)

[15] Alam MS, Naqvi AZ, Kabir-ud-Din, Colloids Surf. B: Biointerfaces, 57, 204 (2007)

[16] Kabir-ud-Din, Rub MA, Naqvi AZ, J. Chem. Eng. Data, 56(7), 3115 (2011)

[17] Kabir-ud-Din, Al-Ahmadi MDA, Naqvi AZ, Akram M, J. Dispersion Sci. Technol., 30, 439 (2009)

[18] Rub MA, Asiri AM, Azum N, Khan A, Khan AAP, Khan SB, Rahman MM, Kabir-ud-Din, J. Ind. Eng. Chem., http://dx.doi.org/10.1016/j.jiec.2013.02.019 (2013)

[19] Britton HTS, 3rd ed., Hydrogen Ions: Their Determination and Importance in Pure and Industrial Chemistry, vol. 2, Chapman, London, 1942.

[20] Attwood D, Florence AT, Surfactant Systems. Their Chemistry, Pharmacy and Biology, Chapman and Hall, New York, 1983.

[21] Khan IA, Khanam AJ, Khan ZA, Kabir-ud-Din, J. Chem. Eng. Data, 55(11), 4775 (2010)

[22] Schick MJ (Ed.), Nonionic Surfactants: Physical Chemistry, Dekker, New York, 1987.

[23] Mosquera V, del Rio JM, Attwood D, Garcia M, Jones MN, Prieto G, Suarez MJ, Sarmiento F, J. Colloid Interface Sci., 206(1), 66 (1998)

[24] Ruiz CC, Diaz-Lopez L, Aguiar J, J. Colloid Interface Sci., 305(2), 293 (2007)

[25] Das C, Das B, J. Chem. Eng. Data, 54(2), 559 (2009)

[26] Lange H, Beck KH, Kolloid Z. Z. Polym., 251, 424 (1973)

[27] Rosen MJ, Surfactants and Interfacial Phenomenon, 3rd ed., Wiley-Interscience, New York, 2004.

[28] Asakawa T, Kitano H, Ohta A, Miyagishi S, J. Colloid Interface Sci., 242(2), 284 (2001)

[29] Iijima H, Kato T, Soderman O, Langmuir, 16(2), 318 (2000)

[30] Rosen MJ, Aronson S, Colloids Surf., 3, 201 (1981)

[31] Sugihara G, Miyazono AM, Nagadome S, Oida T, Hayashi Y, Ko JS, J. Oleo Sci., 52, 449 (2003)

[32] Hoffmann H, Possnecker G, Langmuir, 10(2), 381 (1994)

[33] Maeda H, J. Phys. Chem. B, 109(33), 15933 (2005)

[34] Katzung BG, Basic and Clinical Pharmacology, 9th ed., McGraw Hill, New York, 2004

[35] Laughlin RG, Adv. Liq. Crystals, 3, 41 (1978)

[36] Rao URK, Manohar C, Valaulikar BS, Iyer RM, J. Phys. Chem., 91, 3286 (1987)