Wet grinding experiments were carried out to optimize the cost of grinding media and energy consumption by adding different amount of finer to coarser grinding media. The effects of amount of finer media and finer to coarser grinding media size ratio were investigated. Much smaller product particle sizes were obtained with lesser amount of energy consumption by mixed media grinding. Nanogrinding performance was evaluated by mixing grinding media of different sizes based on the stress energy model. Rheological analysis of ground nanosuspension was conducted to elucidate the role of finer grinding media to improve the wet grinding process.