Preparation of poly acrylic acid grafted-mesoporous silica as pH responsive releasing material

Chanatip Samart; Piyawan Prawingwong; Sittipong Amnuaypanich; Haibo Zhang; Koji Kajiyoshi; Prasert Reubroycharoen

Journal of Industrial and Engineering Chemistry, Vol.20, No.4, 2153-2158, July, 2014

DOI10.1016/j.jiec.2013.09.045 Export Citation

Preparation of poly acrylic acid grafted-mesoporous silica as pH responsive releasing material

Chanatip Samart^†, Piyawan Prawingwong, Sittipong Amnuaypanich¹, Haibo Zhang², Koji Kajiyoshi³, and Prasert Reubroycharoen⁴

Green Innovative Chemistry Research Unit, Department of Chemistry, Thammasat University, Klongluang, Pathumtani 12120, Thailand
¹Materials Chemistry Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
²College of Material Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
³Research Laboratory of Hydrothermal Chemistry, Faculty of Science, Kochi University, Kochi 780-8520, Japan
⁴Department of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand

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Poly acrylic acid (PAA)-grafted-mesoporous silica (MS) obtained from rice husk ash was investigated for its drug loading and pH-switching release behavior using indigo carmine as a model payload drug. When grafting PAA onto the optimally synthesized MS by UV-irradiation, the grafting efficiency was increased with increasing polymerization time and monomer concentration. Indigo carmine release was less than 10% of that initially loaded into the PAA-g-MS carrier when incubated at pH 2, but at pH 8 the indigo carmine showed a sustained release to >93% after 7.5 h. PAA-g-MS has the potential to be a pHresponsive drug delivery system.

Keywords:Mesoporous silica;pH-responsive controlled release;Poly(acrylic acid) grafted;Indigo carmine;Drug delivery vehicle

[References]

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Yuan L, Tang Q, Yang D, Zhang JZ, Zhang F, Hu J, J. Phys. Chem. C, 115, 9926 (2011)

[Referenced By]

[1] Wang X, Venkatraman SS, Boey FYC, Loo JSC, Tan LP, Biomaterials, 27, 5588 (2006)

[2] Guo XD, Zhang LJ, Qian Y, Zhou J, Chem. Eng. J., 131(1-3), 195 (2007)

[3] Ruan G, Feng S, Lic Q, J. Control. Release, 84, 151 (2002)

[4] Zhu Y, Shi J, Microporous Mesoporous Mater., 103, 243 (2007)

[5] Li Z, Wen L, Shao L, Chen J, J. Control. Release, 98, 245 (2004)

[6] Ren T, Yuan Z, Su B, Colloids Surf. A: Physicochem. Eng. Asp., 300, 79 (2007)

[7] Heikkil T, Salonen J, Tuura J, Hamdy MS, Mul G, Kumar N, Salmi T, Murzin DY, Laitinen L, Kaukonen AM, Hirvonen J, Lehto VP, Int. J. Pharm., 331, 133 (2007)

[8] Gao Q, Xu Y, Wu D, Sun Y, Li X, J. Phys. Chem. C, 113, 12753 (2009)

[9] Ma HM, Davis RH, Bowman CN, Macromolecules, 33(2), 331 (2000)

[10] Wang Q, Liu LY, Yang WT, Polymer, 48(22), 6581 (2007)

[11] Srivastava VC, Mall ID, Mishra IM, J. Hazard. Mater., 134(1-3), 257 (2006)

[12] Jullaphan O, Witoon T, Chareonpanich M, Mater. Lett., 63, 1303 (2009)

[13] Jang HT, Park YK, Ko YS, Lee JY, Margandan B, Int. J. Greenhouse Gas Control, 3, 545 (2009)

[14] Cheng Y, Lu M, Li JS, Su XY, Pan SL, Jiao C, Peng MH, J. Colloid Interface Sci., 369, 388 (2012)

[15] Jiang L, Gao Q, Yu Y, Wu D, Wu Z, Wang W, Yang W, Jin R, Smart Mater. Struct., 16, 2169 (2007)

[16] Yuan L, Tang Q, Yang D, Zhang JZ, Zhang F, Hu J, J. Phys. Chem. C, 115, 9926 (2011)