Materials and fabrication approaches that allow integration of biodegradable/transient electronics onto diverse classes of biodegradable substrates are presented in this article. By first depositing, patterning, and etching the materials for the electronics and then integrating them on a substrate of interest, it is possible to use nearly any type of biodegradable material for this purpose. Component and system-level studies of various devices and biodegradable polymers illustrate the capabilities and operational aspects. Dissolution studies and mechanics modeling results highlight different modes for transient behavior.