The aim of this study was to assess the disinfection of a real secondary effluent from a municipal wastewater treatment plant using added H2O2 (20 and 50 mg L-1), TiO2 (100 mg L-1) and photo-Fenton under natural solar radiation in compound parabolic collector photo-reactors. For this purpose, the naturally occurring Escherichia coil, spores of sulphite-reducing clostridia (SRC), somatic coliphages (SOMCPH) and F-specific RNA bacteriophages (FRNA) were tested before and along the different solar treatments. Results for E. coil showed the different treatments efficiency rank: photo-Fenton pH 3 > H2O2 (20 mg L-1)/solar > TiO2/solar > solar photo-inactivation. On the other hand, for viral indicators the ranking was: photo-Fenton pH 3> TiO2/solar > H2O2 (20 mg L-1)/solar > solar photo-inactivation. SRC was the most resistant indicator microorganism in all the evaluated processes. For the first time these solar processes have been evaluated for naturally occurring conventional indicators such as E. coil and alternative indicators such as SOMCPH and FRNA as viral indicators or spores of SRC as protozoan indicators. Some of the tested solar photo-oxidation treatments have shown their capability to reduce E. coil concentrations to a suitable level for water reuse (according to different reclaimed water guidelines) within affordable treatment times. (C) 2013 Elsevier B.V. All rights reserved.