Homogeneous-reinforced (HR) polyvinylidene fluoride (PVDF) hollow fiber membranes include PVDF polymer solutions (coating layer) and the matrix membrane prepared through the dry-wet spinning process. The performance of HR membranes varies with the polymer concentration in the polymer solutions and is characterized in terms of pure water flux, rejection of protein, porosity, infiltration property, a mechanical strength test, and morphology observations by a field emission scanning electron microscope (FESEM). The results of this study indicate that the tensile strength of the HR PVDF membranes decreases slights compared with that of the matrix membrane, but the elongation at break increases much more and the hollow fiber membranes are endowed with better flexibility performance. The HR PVDF hollow fiber membranes have a favorable interfacial bonding between the coating layer and the matrix membrane, as shown by FESEM. The infiltration property is characterized by the contact angle experiments. Pure water flux decreases while the rejection ratio with an increase in polymer concentration increasing. The protein solution flux of the HR PVDF membranes is higher than that of the matrix membrane after 100 min of infiltration. Crown Copyright (C) 2012 Published by Elsevier B. V. All rights reserved.