We consider the problem of trajectory generation for constrained differentially flat systems. Based on the topological properties of the set of admissible steady state values of a flat output we derive conditions which allow for an a priori verification of the feasibility of constrained set-point changes. We propose to utilize this relation to generate feasible trajectories. To this end we suggest to split the trajectory generation problem into two stages: (a) the planning of geometric reference paths in the flat output space combined with (b) an assignment of a dynamic motion to these paths. This assignment is based on a reduced optimal control problem. The unique feature of the approach is that due to the specific construction of the paths the optimal control problem to be solved is guaranteed to be feasible. To illustrate our results we consider a Van de Vusse reactor as an example.(C) 2014 Elsevier Ltd. All rights reserved.