Chemistry Letters, Vol.43, No.3, 322-324, 2014
Degradation Properties and pH-responsive Guest-release of Cyclophanes Having Four Ester Side Chains with Terminal Choline Residues
Water-soluble cationic cyclophane 1 having four ester side chains with terminal choline residues was synthesized as a pH-responsive degradable host. Alkaline hydrolysis of the ester bonds of 1 gave the corresponding tetraanionic cyclophane 2, which exhibited guest-binding affinities that led to release of the entrapped anionic guest molecules into the bulk aqueous phase.